DegronMD

Uniprot ID: Q00056

Source protein: Homeobox protein Hox-A4

Source gene: HOXA4

Class: LIG_APCC_ABBA_1

Location: 17:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7868

ASA_SCORE: 53.9167

COIL: 0.7222

CONS_SCORE: 0.3721

DSS_SCORE: 0.5251

HELIX: 0.2483

FCONS_SCORE: 0.9213

RIG_SCORE: 0.7382

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y23H	TCGA-F7-A624	HNSC	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.3056
p.Y23H	DO230312	COCA	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.3056
p.Y23H	DO44440	HNSC	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.3056
p.Y23C	DO34120	PACA	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.3056
p.G31A	DO231631	LINC	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.0833
p.L7S	TCGA-NI-A8LF	LIHC	TCGA	FPPFEE	LIG_APCC_ABBA_1	0.0556
p.L7S	DO49715	LIHC	ICGC	FPPFEE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	LIG_APCC_ABBA_1	600:605	FPPFEE	APC,CDC20,FZR1	0.9867	More...
Q00056	Homeobox protein Hox-A4	LIG_APCC_ABBA_1	17:22	FPPFEE	APC,CDC20,FZR1	0.7868	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons