DegronMD - O14686(KMT2D)

FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17500065). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.

GO - Biological processes (BP): beta-catenin-TCF complex assembly [GO:1904837]; heterochromatin assembly [GO:0031507]; histone H3-K4 dimethylation [GO:0044648]; histone H3-K4 methylation [GO:0051568]; histone H3-K4 monomethylation [GO:0097692]; histone H3-K4 trimethylation [GO:0080182]; oocyte growth [GO:0001555]; oogenesis [GO:00... View more >>

GO - Molecular function (MF): DNA binding [GO:0003677]; histone binding [GO:0042393]; histone methyltransferase activity (H3-K4 specific) [GO:0042800]; metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]

GO - Cellular component (CC): histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DPYSRPP	CBL_PTK	CBL	Histone-lysine N-methyltransferase 2D	2448:2454	More..
SGSTGE	DEG_Kelch_Keap1_1	KEAP1	Histone-lysine N-methyltransferase 2D	2598:2603	More..
PLTPRAS	DEG_SCF_FBW7_1	FBXW7	Histone-lysine N-methyltransferase 2D	2330:2336	More..
VHPTPPPS	DEG_SCF_FBW7_1	FBXW7	Histone-lysine N-methyltransferase 2D	4305:4312	More..
PPTPPSS	DEG_SCF_FBW7_1	FBXW7	Histone-lysine N-methyltransferase 2D	4619:4625	More..
LPPTPPPS	DEG_SCF_FBW7_1	FBXW7	Histone-lysine N-methyltransferase 2D	4626:4633	More..
PGDTPTDE	DEG_SCF_FBW7_2	FBXW7	Histone-lysine N-methyltransferase 2D	377:384	More..
PTTPTTE	DEG_SCF_FBW7_2	FBXW7	Histone-lysine N-methyltransferase 2D	1984:1990	More..
PSTPGPE	DEG_SCF_FBW7_2	FBXW7	Histone-lysine N-methyltransferase 2D	2838:2844	More..
IATPKVE	DEG_SCF_FBW7_2	FBXW7	Histone-lysine N-methyltransferase 2D	3136:3142	More..
EPRAPVAPT	DEG_SIAH_1	SIAH1,SIAH2,SIAH3	Histone-lysine N-methyltransferase 2D	1187:1195	More..
PPSST	DEG_SPOP_SBC_1	SPOP	Histone-lysine N-methyltransferase 2D	2967:2971	More..
PFSSS	DEG_SPOP_SBC_1	SPOP	Histone-lysine N-methyltransferase 2D	3172:3176	More..
PPTY	ITCH	ITCH,NEDD4	Histone-lysine N-methyltransferase 2D	2193:2196	More..
FPPFEE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Histone-lysine N-methyltransferase 2D	600:605	More..
MEVYPE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Histone-lysine N-methyltransferase 2D	1166:1171	More..

Showing 1 to 16 of 16 entries

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2969L	TCGA-EE-A2GL	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation altering degron motif	0.8778
p.S2969L	DO37434	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation altering degron motif	0.8778
p.S2451F	SIDM00973	Melanoma	GDSC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7982
p.S2451F	ACH-000827	Skin Cancer	CCLE	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7982
p.S2451F	WM793B	skin	COSMIC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7982
p.P1194H	DO229054	LICA	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7694
p.P2841L	SIDM00487	Colorectal Carcinoma	GDSC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation altering degron motif	0.7582
p.P2841L	ACH-000963	Colon/Colorectal Cancer	CCLE	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation altering degron motif	0.7582
p.P2841L	CCK-81	large intestine	COSMIC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation altering degron motif	0.7582
p.R2334W	TCGA-VS-A959	CESC	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7523
p.R2334W	DO51640	CESC	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7523
p.R2334L	TCGA-EE-A2GH	SKCM	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7316
p.R2334L	DO37643	SKCM	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7316
p.T1164I	SIDM00447	B-Lymphoblastic Leukemia	GDSC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation blocking phosphorylation signal	0.7222
p.T1164I	ACH-000960	Leukemia	CCLE	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation blocking phosphorylation signal	0.7222
p.T1164I	REH	haematopoietic and lymphoid tissue	COSMIC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation blocking phosphorylation signal	0.7222
p.R2452H	TCGA-06-5416	GBM	TCGA	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7133
p.R2452H	DO10880	GBM	ICGC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7133
p.R1189H	TCGA-AX-A2HD	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.R1189H	TCGA-B5-A3FC	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133

Showing 1 to 20 of 249 entries

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No resistance data available for this Degron.

Kaplan plot for KMT2D in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KMT2D

UniProt ID: O14686

Entrez ID: 8085

Protein name: Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for KMT2D in