DegronMD - O14686(KMT2D)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2975C	TCGA-06-0743	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2222
p.R2975C	DO12364	GBM	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2222
p.R2452H	TCGA-06-5416	GBM	TCGA	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7133
p.R2452H	DO10880	GBM	ICGC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7133
p.R2966W	TCGA-64-1676	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.3056
p.R2966W	DO23629	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.3056
p.T2601I	TCGA-64-1679	LUAD	TCGA	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation altering degron motif	0.7078
p.T2601I	DO26200	LUAD	ICGC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation altering degron motif	0.7078
p.I1200M	TCGA-66-2744	LUSC	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.1944
p.I1200M	DO27025	LUSC	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.1944
p.G3171W	TCGA-A5-A0G1	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.3056
p.G3171W	DO42472	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.3056
p.S370R	TCGA-A5-A1OJ	UCEC	TCGA	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1389
p.S370R	DO229029	LICA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1389
p.S370R	DO42496	UCEC	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1389
p.S1997P	TCGA-A6-5666	COAD	TCGA	PTTPTTE	DEG_SCF_FBW7_2	1984:1990	Mutation rewiring degron network	0.1389
p.S1997P	DO9482	COAD	ICGC	PTTPTTE	DEG_SCF_FBW7_2	1984:1990	Mutation rewiring degron network	0.1389
p.R598H	TCGA-A6-6781	COAD	TCGA	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.2778
p.R598H	TCGA-JY-A93D	ESCA	TCGA	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.2778
p.R598H	TCGA-XK-AAIW	PRAD	TCGA	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.2778
p.R598H	DO8447	COAD	ICGC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.2778
p.R598H	DO51407	PRAD	ICGC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.2778
p.R2611C	TCGA-AA-3660	COAD	TCGA	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1111
p.R2611C	DO7795	COAD	ICGC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1111
p.P602S	TCGA-AP-A059	UCEC	TCGA	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation altering degron motif	0.6752
p.P602S	DO41361	UCEC	ICGC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation altering degron motif	0.6752
p.T2203K	TCGA-AP-A0LM	UCEC	TCGA	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.1389
p.T2203K	DO43306	UCEC	ICGC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.1389
p.R4319I	TCGA-AP-A1E0	UCEC	TCGA	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1389
p.R4319I	TCGA-MP-A4TF	LUAD	TCGA	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1389
p.R4319I	DO45316	LUAD	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1389
p.R4319I	DO43154	UCEC	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1389
p.A2329T	TCGA-AX-A063	UCEC	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.3056
p.A2329T	DO42201	UCEC	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.3056
p.A2849V	TCGA-AX-A2HC	UCEC	TCGA	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.1944
p.A2849V	DO41572	UCEC	ICGC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.1944
p.R2443H	TCGA-AX-A2HC	UCEC	TCGA	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1944
p.R2443H	DO41572	UCEC	ICGC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1944
p.R2975H	TCGA-AX-A2HD	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2222
p.R2975H	TCGA-ND-A4WC	UCS	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2222
p.R2975H	DO42608	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2222
p.R1189H	TCGA-AX-A2HD	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.R1189H	TCGA-B5-A3FC	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.R1189H	DO41871	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.R1189H	DO42608	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.R1189H	SIDM01090	Colorectal Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.R1189H	ACH-000943	Colon/Colorectal Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.R1189H	RKO	large intestine	COSMIC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7133
p.G1179D	TCGA-B5-A3FA	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.1111
p.G1179D	TCGA-B5-A3FA	UCEC	TCGA	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation rewiring degron network	0.1111
p.G1179D	DO52402	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.1111
p.G1179D	DO52402	UCEC	ICGC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation rewiring degron network	0.1111
p.R2334Q	TCGA-BR-4201	STAD	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.6218
p.R2334Q	DO38707	STAD	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.6218
p.V390A	TCGA-BR-4368	STAD	TCGA	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1667
p.V390A	DO38715	STAD	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1667
p.V2440I	TCGA-CG-5721	STAD	TCGA	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1111
p.V2440I	TCGA-G7-6790	KIRP	TCGA	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1111
p.V2440I	DO20888	KIRP	ICGC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1111
p.V2440I	DO38192	STAD	ICGC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1111
p.R371G	TCGA-CV-7435	HNSC	TCGA	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1667
p.R371G	DO14918	HNSC	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1667
p.N2977Y	TCGA-D1-A103	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.1667
p.N2977Y	DO42312	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.1667
p.S2604G	TCGA-D1-A103	UCEC	TCGA	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.3056
p.S2604G	DO42312	UCEC	ICGC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.3056
p.V1205I	TCGA-D1-A103	UCEC	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.0556
p.V1205I	DO42312	UCEC	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.0556
p.D2325N	TCGA-EA-A3HQ	CESC	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.1944
p.D2325N	DO6317	CESC	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.1944
p.A2192T	TCGA-EE-A181	SKCM	TCGA	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.3056
p.A2192T	DO37444	SKCM	ICGC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.3056
p.R2334L	TCGA-EE-A2GH	SKCM	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7316
p.R2334L	DO37643	SKCM	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7316
p.S2969L	TCGA-EE-A2GL	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation altering degron motif	0.8778
p.S2969L	DO37434	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation altering degron motif	0.8778
p.A3144T	TCGA-EI-6882	READ	TCGA	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.2778
p.A3144T	DO36531	READ	ICGC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.2778
p.A3144T	SIDM00045	Gastric Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.2778
p.A3144T	ACH-002141	Gastric Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.2778
p.A3144T	HSC-39	stomach	COSMIC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.2778
p.L2981V	TCGA-EJ-8468	PRAD	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.0556
p.L2981V	DO48517	PRAD	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.0556
p.G2595W	TCGA-EM-A2CJ	THCA	TCGA	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.25
p.G2595W	DO39360	THCA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.25
p.P2200H	TCGA-EO-A22R	UCEC	TCGA	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2222
p.P2200H	DO42713	UCEC	ICGC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2222
p.L4302F	TCGA-EO-A22U	UCEC	TCGA	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.25
p.L4302F	DO43755	UCEC	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.25
p.P2202S	TCGA-ER-A194	SKCM	TCGA	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.1667
p.P2202S	DO47646	SKCM	ICGC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.1667
p.R598C	TCGA-F1-6177	STAD	TCGA	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.2778
p.R598C	DO38727	STAD	ICGC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.2778
p.E2972G	TCGA-F4-6703	COAD	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.3056
p.E2972G	DO9908	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.3056
p.E3181D	TCGA-G2-A2EL	BLCA	TCGA	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.1944
p.E3181D	DO478	BLCA	ICGC	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.1944
p.E3181D	DO229052	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.1944
p.S606F	TCGA-GN-A263	SKCM	TCGA	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.3056
p.S606F	DO37766	SKCM	ICGC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.3056
p.Q2337E	TCGA-IR-A3LL	CESC	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.3056
p.Q2337E	DO44362	CESC	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.3056
p.R2460L	TCGA-J9-A52C	PRAD	TCGA	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1667
p.R2460L	DO51343	PRAD	ICGC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.1667
p.V2964F	TCGA-KN-8422	KICH	TCGA	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.25
p.V2964F	DO220449	KICH	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.25
p.Q1178H	TCGA-LN-A9FP	ESCA	TCGA	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.0833
p.Q1178H	TCGA-LN-A9FP	ESCA	TCGA	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation rewiring degron network	0.1389
p.P2340S	TCGA-N5-A4RD	UCS	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.2222
p.R2334W	TCGA-VS-A959	CESC	TCGA	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7523
p.R2334W	DO51640	CESC	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation altering degron motif	0.7523
p.S2590L	TCGA-YZ-A985	UVM	TCGA	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1111
p.K2322E	DO9700	COAD	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation substituting flanking lysine	0.2222
p.T1175I	DO234269	ESAD	ICGC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation rewiring degron network	0.2222
p.V390I	DO228542	GACA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1667
p.G3151S	DO233154	GACA	ICGC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.0833
p.G3151S	DO35275	PACA	ICGC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.0833
p.P2343L	DO233784	GACA	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.1389
p.P2343L	DO233918	GACA	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.1389
p.R2847C	DO233903	GACA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.25
p.P3131L	DO11854	GBM	ICGC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.1944
p.T1974M	DO14678	HNSC	ICGC	PTTPTTE	DEG_SCF_FBW7_2	1984:1990	Mutation rewiring degron network	0.0556
p.T2323K	DO228952	LICA	ICGC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation blocking phosphorylation signal	0.5833
p.P2596T	DO229018	LICA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.2778
p.T2971N	DO229018	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation altering degron motif	0.7055
p.R2975S	DO229028	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2222
p.P2853Q	DO229028	LICA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.0833
p.A2464D	DO229025	LICA	ICGC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.0556
p.P381T	DO229027	LICA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation altering degron motif	0.7031
p.Q2848K	DO229026	LICA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.2222
p.A391E	DO229035	LICA	ICGC	PGDTPTDE	DEG_SCF_FBW7_2	377:384	Mutation rewiring degron network	0.1389
p.Q4322K	DO229037	LICA	ICGC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.0556
p.P1170H	DO229045	LICA	ICGC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation altering degron motif	0.6583
p.P1194H	DO229054	LICA	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.7694
p.Q1178K	DO229009	LICA	ICGC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.0833
p.Q1178K	DO229009	LICA	ICGC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation rewiring degron network	0.1389
p.A3144V	DO231848	LINC	ICGC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.2778
p.S2608T	DO220886	MELA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1944
p.P2613S	DO222413	MELA	ICGC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.0556
p.S2828F	DO222775	MELA	ICGC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.0556
p.P1984S	DO222843	MELA	ICGC	PTTPTTE	DEG_SCF_FBW7_2	1984:1990	Mutation altering degron motif	0.6752
p.L599V	DO51527	PACA	ICGC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.3056
p.Y1169C	DO224734	PACA	ICGC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation altering degron motif	0.7087
p.A3144S	DO228138	PBCA	ICGC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.2778
p.G1975S	DO232224	PBCA	ICGC	PTTPTTE	DEG_SCF_FBW7_2	1984:1990	Mutation rewiring degron network	0.0833
p.V4639A	DO229227	THCA	ICGC	LPPTPPPS	DEG_SCF_FBW7_1	4626:4633	Mutation rewiring degron network	0.1667
p.R2611H	SIDM02041	Colorectal Carcinoma	GDSC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1111
p.R2611H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1111
p.R2611H	ACH-002256	Leukemia	CCLE	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1111
p.R2611H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1111
p.V4301A	SIDM02059	Colorectal Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.2222
p.L4616P	SIDM00334	Endometrial Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	4619:4625	Mutation rewiring degron network	0.25
p.L4616P	SIDM00334	Endometrial Carcinoma	GDSC	LPPTPPPS	DEG_SCF_FBW7_1	4626:4633	Mutation rewiring degron network	0.0556
p.L4616P	ACH-000879	Endometrial/Uterine Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	4619:4625	Mutation rewiring degron network	0.25
p.L4616P	ACH-000879	Endometrial/Uterine Cancer	CCLE	LPPTPPPS	DEG_SCF_FBW7_1	4626:4633	Mutation rewiring degron network	0.0556
p.S2451F	SIDM00973	Melanoma	GDSC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7982
p.S2451F	ACH-000827	Skin Cancer	CCLE	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7982
p.S2451F	WM793B	skin	COSMIC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.7982
p.R2452S	SIDM00973	Melanoma	GDSC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.6316
p.R2452S	ACH-000827	Skin Cancer	CCLE	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.6316
p.R2452S	WM793B	skin	COSMIC	DPYSRPP	CBL_PTK	2448:2454	Mutation altering degron motif	0.6316
p.R3167Q	SIDM01151	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.1944
p.R3167Q	ACH-000483	Liver Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.1944
p.R3167Q	SNU-182	liver	COSMIC	PFSSS	DEG_SPOP_SBC_1	3172:3176	Mutation rewiring degron network	0.1944
p.P1191L	SIDM00330	Neuroblastoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6471
p.P1191L	SIDM00050	Chondrosarcoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6471
p.P1191L	SIDM00870	Breast Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6471
p.P1191L	SIDM01679	Small Cell Lung Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6471
p.P1191L	SIDM01504	Small Cell Lung Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6471
p.T2323A	SIDM00845	Burkitt's Lymphoma	GDSC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation blocking phosphorylation signal	0.5833
p.T2323A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation blocking phosphorylation signal	0.5833
p.T2323A	SIDM00461	Acute Myeloid Leukemia	GDSC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation blocking phosphorylation signal	0.5833
p.T2323A	ACH-000786	Lymphoma	CCLE	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation blocking phosphorylation signal	0.5833
p.V4305I	SIDM00427	Ewing's Sarcoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation altering degron motif	0.5965
p.V4305I	SIDM00506	Small Cell Lung Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation altering degron motif	0.5965
p.V4305I	SIDM00795	Melanoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation altering degron motif	0.5965
p.V4305I	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation altering degron motif	0.5965
p.P4620L	SIDM00602	Gastric Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	4619:4625	Mutation altering degron motif	0.6471
p.P4620L	ACH-000919	Gastric Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	4619:4625	Mutation altering degron motif	0.6471
p.P4620L	IM-95	stomach	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	4619:4625	Mutation altering degron motif	0.6471
p.P4628L	SIDM00654	Small Cell Lung Carcinoma	GDSC	LPPTPPPS	DEG_SCF_FBW7_1	4626:4633	Mutation altering degron motif	0.6471
p.P4628L	ACH-000866	Lung Cancer	CCLE	LPPTPPPS	DEG_SCF_FBW7_1	4626:4633	Mutation altering degron motif	0.6471
p.P4628L	NCI-H1048	lung	COSMIC	LPPTPPPS	DEG_SCF_FBW7_1	4626:4633	Mutation altering degron motif	0.6471
p.T1164I	SIDM00447	B-Lymphoblastic Leukemia	GDSC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation blocking phosphorylation signal	0.7222
p.T1164I	ACH-000960	Leukemia	CCLE	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation blocking phosphorylation signal	0.7222
p.T1164I	REH	haematopoietic and lymphoid tissue	COSMIC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation blocking phosphorylation signal	0.7222
p.S597F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.25
p.S597F	ACH-000960	Leukemia	CCLE	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.25
p.S597F	REH	haematopoietic and lymphoid tissue	COSMIC	FPPFEE	LIG_APCC_ABBA_1	600:605	Mutation rewiring degron network	0.25
p.T2191M	SIDM00210	Ovarian Carcinoma	GDSC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2778
p.T2191M	ACH-000657	Ovarian Cancer	CCLE	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2778
p.T2191M	A2780	ovary	COSMIC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2778
p.P2457L	SIDM00313	Hodgkin's Lymphoma	GDSC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.25
p.P2457L	ACH-000702	Lymphoma	CCLE	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.25
p.P2457L	L-1236	haematopoietic and lymphoid tissue	COSMIC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.25
p.S3130F	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation blocking phosphorylation signal	0.6111
p.S3130F	ACH-000824	Esophageal Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation blocking phosphorylation signal	0.6111
p.S3130F	KYSE-510	oesophagus	COSMIC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation blocking phosphorylation signal	0.6111
p.Q4315E	SIDM01148	Plasma Cell Myeloma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.25
p.Q4315E	ACH-000050	Myeloma	CCLE	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.25
p.Q4315E	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.25
p.S4297F	SIDM01148	Plasma Cell Myeloma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1111
p.S4297F	ACH-000050	Myeloma	CCLE	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1111
p.S4297F	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1111
p.Q2337K	SIDM01148	Plasma Cell Myeloma	GDSC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.3056
p.Q2337K	ACH-000050	Myeloma	CCLE	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.3056
p.Q2337K	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	PLTPRAS	DEG_SCF_FBW7_1	2330:2336	Mutation rewiring degron network	0.3056
p.G2846C	SIDM00282	Colorectal Carcinoma	GDSC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.2778
p.G2846C	ACH-000998	Colon/Colorectal Cancer	CCLE	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.2778
p.G2846C	CW-2	large intestine	COSMIC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation rewiring degron network	0.2778
p.R3127C	SIDM00418	Thyroid Gland Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.0833
p.R3127C	ACH-000716	Thyroid Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.0833
p.R3127C	TT2609-C02	thyroid	COSMIC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.0833
p.P1188S	SIDM00878	Breast Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6752
p.P1188S	ACH-000930	Breast Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6752
p.P1188S	HCC1569	breast	COSMIC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6752
p.T4298I	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1389
p.T4298I	ACH-000675	Lung Cancer	CCLE	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1389
p.T4298I	NCI-H1734	lung	COSMIC	VHPTPPPS	DEG_SCF_FBW7_1	4305:4312	Mutation rewiring degron network	0.1389
p.P2841L	SIDM00487	Colorectal Carcinoma	GDSC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation altering degron motif	0.7582
p.P2841L	ACH-000963	Colon/Colorectal Cancer	CCLE	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation altering degron motif	0.7582
p.P2841L	CCK-81	large intestine	COSMIC	PSTPGPE	DEG_SCF_FBW7_2	2838:2844	Mutation altering degron motif	0.7582
p.A1193S	SIDM00292	Small Cell Lung Carcinoma	GDSC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6477
p.A1193S	ACH-002077	Lung Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6477
p.A1193S	LU-165	lung	COSMIC	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation altering degron motif	0.6477
p.M1166V	SIDM00214	Colorectal Carcinoma	GDSC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation altering degron motif	0.6097
p.M1166V	ACH-000955	Colon/Colorectal Cancer	CCLE	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation altering degron motif	0.6097
p.M1166V	SNU-407	large intestine	COSMIC	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation altering degron motif	0.6097
p.T2191K	SIDM01173	Rhabdomyosarcoma	GDSC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2778
p.T2191K	ACH-000772	Sarcoma	CCLE	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2778
p.T2191K	TE-441-T	soft tissue	COSMIC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.2778
p.R2456C	SIDM01609	Endometrial Carcinoma	GDSC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.2778
p.R2456C	SIDM01617	Endometrial Carcinoma	GDSC	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.2778
p.R2456C	ACH-000972	Endometrial/Uterine Cancer	CCLE	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.2778
p.R2456C	ACH-000994	Endometrial/Uterine Cancer	CCLE	DPYSRPP	CBL_PTK	2448:2454	Mutation rewiring degron network	0.2778
p.P2190H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.25
p.P2190H	ACH-000964	Leukemia	CCLE	PPTY	ITCH	2193:2196	Mutation rewiring degron network	0.25
p.G2591C	SIDM01685	B-Lymphoblastic Leukemia	GDSC	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1389
p.G2591C	ACH-000130	Leukemia	CCLE	SGSTGE	DEG_Kelch_Keap1_1	2598:2603	Mutation rewiring degron network	0.1389
p.R3127H	SIDM01729	Endometrial Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.0833
p.R3127H	ACH-000909	Endometrial/Uterine Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.0833
p.N2965T	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2778
p.N2965T	ACH-000942	Leukemia	CCLE	PPSST	DEG_SPOP_SBC_1	2967:2971	Mutation rewiring degron network	0.2778
p.L1199V	ACH-000923	Lymphoma	CCLE	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.2222
p.P1162H	ACH-000941	Endometrial/Uterine Cancer	CCLE	MEVYPE	LIG_APCC_ABBA_1	1166:1171	Mutation rewiring degron network	0.2222
p.T1989A	ACH-000951	Lung Cancer	CCLE	PTTPTTE	DEG_SCF_FBW7_2	1984:1990	Mutation altering degron motif	0.6028
p.T1989A	NCI-H2342	lung	COSMIC	PTTPTTE	DEG_SCF_FBW7_2	1984:1990	Mutation altering degron motif	0.6028
p.S3149P	ACH-000982	Colon/Colorectal Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	3136:3142	Mutation rewiring degron network	0.1389
p.P1197H	ACH-000985	Colon/Colorectal Cancer	CCLE	EPRAPVAPT	DEG_SIAH_1	1187:1195	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KMT2D

UniProt ID: O14686

Entrez ID: 8085

Protein name: Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KMT2D in