DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: DEG_SCF_FBW7_2

Location: 3136:3142

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 103.5286

COIL: 0.9377

CONS_SCORE: 0.3793

DSS_SCORE: 0.5191

HELIX: 0.0157

FCONS_SCORE: 0.9968

RIG_SCORE: 0.7417

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3130F	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	0.6111
p.S3130F	ACH-000824	Esophageal Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	0.6111
p.S3130F	KYSE-510	oesophagus	COSMIC	IATPKVE	DEG_SCF_FBW7_2	0.6111
p.A3144T	TCGA-EI-6882	READ	TCGA	IATPKVE	DEG_SCF_FBW7_2	0.2778
p.A3144T	DO36531	READ	ICGC	IATPKVE	DEG_SCF_FBW7_2	0.2778
p.A3144T	SIDM00045	Gastric Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	0.2778
p.A3144T	ACH-002141	Gastric Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	0.2778
p.A3144T	HSC-39	stomach	COSMIC	IATPKVE	DEG_SCF_FBW7_2	0.2778
p.A3144V	DO231848	LINC	ICGC	IATPKVE	DEG_SCF_FBW7_2	0.2778
p.A3144S	DO228138	PBCA	ICGC	IATPKVE	DEG_SCF_FBW7_2	0.2778
p.P3131L	DO11854	GBM	ICGC	IATPKVE	DEG_SCF_FBW7_2	0.1944
p.S3149P	ACH-000982	Colon/Colorectal Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	0.1389
p.G3151S	DO233154	GACA	ICGC	IATPKVE	DEG_SCF_FBW7_2	0.0833
p.G3151S	DO35275	PACA	ICGC	IATPKVE	DEG_SCF_FBW7_2	0.0833
p.R3127C	SIDM00418	Thyroid Gland Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	0.0833
p.R3127C	ACH-000716	Thyroid Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	0.0833
p.R3127C	TT2609-C02	thyroid	COSMIC	IATPKVE	DEG_SCF_FBW7_2	0.0833
p.R3127H	SIDM01729	Endometrial Carcinoma	GDSC	IATPKVE	DEG_SCF_FBW7_2	0.0833
p.R3127H	ACH-000909	Endometrial/Uterine Cancer	CCLE	IATPKVE	DEG_SCF_FBW7_2	0.0833

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SCF_FBW7_2	3136:3142	IATPKVE	FBXW7	0.9934	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons