DegronMD

Uniprot ID: O14686

Source protein: Histone-lysine N-methyltransferase 2D

Source gene: KMT2D

Class: ITCH

Location: 2193:2196

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9967

ASA_SCORE: 112.525

COIL: 0.975

CONS_SCORE: 0.3538

DSS_SCORE: 0.6417

HELIX: 0.0078

FCONS_SCORE: 0.9823

RIG_SCORE: 0.5882

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2192T	TCGA-EE-A181	SKCM	TCGA	PPTY	ITCH	0.3056
p.A2192T	DO37444	SKCM	ICGC	PPTY	ITCH	0.3056
p.T2191M	SIDM00210	Ovarian Carcinoma	GDSC	PPTY	ITCH	0.2778
p.T2191M	ACH-000657	Ovarian Cancer	CCLE	PPTY	ITCH	0.2778
p.T2191M	A2780	ovary	COSMIC	PPTY	ITCH	0.2778
p.T2191K	SIDM01173	Rhabdomyosarcoma	GDSC	PPTY	ITCH	0.2778
p.T2191K	ACH-000772	Sarcoma	CCLE	PPTY	ITCH	0.2778
p.T2191K	TE-441-T	soft_tissue	COSMIC	PPTY	ITCH	0.2778
p.P2190H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPTY	ITCH	0.25
p.P2190H	ACH-000964	Leukemia	CCLE	PPTY	ITCH	0.25
p.P2200H	TCGA-EO-A22R	UCEC	TCGA	PPTY	ITCH	0.2222
p.P2200H	DO42713	UCEC	ICGC	PPTY	ITCH	0.2222
p.P2202S	TCGA-ER-A194	SKCM	TCGA	PPTY	ITCH	0.1667
p.P2202S	DO47646	SKCM	ICGC	PPTY	ITCH	0.1667
p.T2203K	TCGA-AP-A0LM	UCEC	TCGA	PPTY	ITCH	0.1389
p.T2203K	DO43306	UCEC	ICGC	PPTY	ITCH	0.1389

Showing 1 to 16 of 16 entries

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Drug responses associated with KMT2D mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPTY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82650	28S ribosomal protein S22, mitochondrial	ITCH	100:103	PPTY	ITCH,NEDD4	0.9899	More...
O14514	Adhesion G protein-coupled receptor B1	ITCH	628:631	PPTY	ITCH,NEDD4	0.9223	More...
Q9UKU9	Angiopoietin-related protein 2	ITCH	227:230	PPTY	ITCH,NEDD4	0.7151	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	1581:1584	PPTY	ITCH,NEDD4	0.9943	More...
Q7Z478	ATP-dependent RNA helicase DHX29	ITCH	459:462	PPTY	ITCH,NEDD4	0.8751	More...
O75175	CCR4-NOT transcription complex subunit 3	ITCH	320:323	PPTY	ITCH,NEDD4	0.7287	More...
O14578	Citron Rho-interacting kinase	ITCH	1926:1929	PPTY	ITCH,NEDD4	0.5412	More...
O75909	Cyclin-K	ITCH	510:513	PPTY	ITCH,NEDD4	0.7979	More...
Q9P2K8	eIF-2-alpha kinase GCN2	ITCH	80:83	PPTY	ITCH,NEDD4	0.7591	More...
Q9H6T0	Epithelial splicing regulatory protein 2	ITCH	584:587	PPTY	ITCH,NEDD4	0.9502	More...
Q9Y6I3	Epsin-1	ITCH	545:548	PPTY	ITCH,NEDD4	0.7626	More...
O14686	Histone-lysine N-methyltransferase 2D	ITCH	2193:2196	PPTY	ITCH,NEDD4	0.9967	More...
Q9BT40	Inositol polyphosphate 5-phosphatase K	ITCH	244:247	PPTY	ITCH,NEDD4	0.9245	More...
P25391	Laminin subunit alpha-1	ITCH	171:174	PPTY	ITCH,NEDD4	0.9366	More...
Q86U70	LIM domain-binding protein 1	ITCH	49:52	PPTY	ITCH,NEDD4	0.9966	More...
O15165	Low-density lipoprotein receptor class A domain-containing protein 4	ITCH	252:255	PPTY	ITCH,NEDD4	0.9918	More...
Q92859	Neogenin	ITCH	1372:1375	PPTY	ITCH,NEDD4	0.9601	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	ITCH	666:669	PPTY	ITCH,NEDD4	0.8045	More...
P23760	Paired box protein Pax-3	ITCH	450:453	PPTY	ITCH,NEDD4	0.9541	More...
P23759	Paired box protein Pax-7	ITCH	444:447	PPTY	ITCH,NEDD4	0.9893	More...
O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ITCH	658:661	PPTY	ITCH,NEDD4	0.6551	More...
Q9UPA5	Protein bassoon	ITCH	1952:1955	PPTY	ITCH,NEDD4	0.8543	More...
A6NMK8	Protein INSYN2B	ITCH	76:79	PPTY	ITCH,NEDD4	0.8124	More...
Q5JSZ5	Protein PRRC2B	ITCH	275:278	PPTY	ITCH,NEDD4	0.8146	More...
Q969W9	Protein TMEPAI	ITCH	229:232	PPTY	ITCH,NEDD4	0.9995	More...

Showing 1 to 25 of 41 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTY

Degron related mutations and impact score

Drug responses associated with KMT2D mutations

All proteins holding degron of PPTY