DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPTY
Uniprot ID:
O14578
Source protein:
Citron Rho-interacting kinase
Source gene:
CIT
Class:
ITCH
Location:
1926:1929
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.5412
ASA_SCORE:
88.6
COIL:
0.862
CONS_SCORE:
0.1973
DSS_SCORE:
0.7983
HELIX:
0.0755
FCONS_SCORE:
0.7506
RIG_SCORE:
0.5256
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y1929H
DO233885
GACA
ICGC
PPTY
ITCH
0.834
p.P1926L
DO2198
BRCA
ICGC
PPTY
ITCH
0.7582
p.A1928V
TCGA-4Z-AA80
BLCA
TCGA
PPTY
ITCH
0.6936
p.T1928M
DO38567
STAD
ICGC
PPTY
ITCH
0.6312
p.T1928K
DO44832
LICA
ICGC
PPTY
ITCH
0.6195
p.R1924Q
DO219069
HNSC
ICGC
PPTY
ITCH
0.2778
p.R1924Q
ACH-000995
Leukemia
CCLE
PPTY
ITCH
0.2778
p.H1932N
DO229031
LICA
ICGC
PPTY
ITCH
0.25
p.A1919D
TCGA-EA-A411
CESC
TCGA
PPTY
ITCH
0.1389
p.R1936H
DO40978
UCEC
ICGC
PPTY
ITCH
0.1389
p.R1918L
DO231152
LUSC
ICGC
PPTY
ITCH
0.1111
p.R1918C
DO220878
MELA
ICGC
PPTY
ITCH
0.1111
p.R1918C
DO37406
SKCM
ICGC
PPTY
ITCH
0.1111
p.R1918H
DO42608
UCEC
ICGC
PPTY
ITCH
0.1111
Showing 1 to 14 of 14 entries
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Drug responses associated with CIT mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPTY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P82650
28S ribosomal protein S22, mitochondrial
ITCH
100:103
PPTY
ITCH,NEDD4
0.9899
More...
O14514
Adhesion G protein-coupled receptor B1
ITCH
628:631
PPTY
ITCH,NEDD4
0.9223
More...
Q9UKU9
Angiopoietin-related protein 2
ITCH
227:230
PPTY
ITCH,NEDD4
0.7151
More...
Q68CP9
AT-rich interactive domain-containing protein 2
ITCH
1581:1584
PPTY
ITCH,NEDD4
0.9943
More...
Q7Z478
ATP-dependent RNA helicase DHX29
ITCH
459:462
PPTY
ITCH,NEDD4
0.8751
More...
O75175
CCR4-NOT transcription complex subunit 3
ITCH
320:323
PPTY
ITCH,NEDD4
0.7287
More...
O14578
Citron Rho-interacting kinase
ITCH
1926:1929
PPTY
ITCH,NEDD4
0.5412
More...
O75909
Cyclin-K
ITCH
510:513
PPTY
ITCH,NEDD4
0.7979
More...
Q9P2K8
eIF-2-alpha kinase GCN2
ITCH
80:83
PPTY
ITCH,NEDD4
0.7591
More...
Q9H6T0
Epithelial splicing regulatory protein 2
ITCH
584:587
PPTY
ITCH,NEDD4
0.9502
More...
Q9Y6I3
Epsin-1
ITCH
545:548
PPTY
ITCH,NEDD4
0.7626
More...
O14686
Histone-lysine N-methyltransferase 2D
ITCH
2193:2196
PPTY
ITCH,NEDD4
0.9967
More...
Q9BT40
Inositol polyphosphate 5-phosphatase K
ITCH
244:247
PPTY
ITCH,NEDD4
0.9245
More...
P25391
Laminin subunit alpha-1
ITCH
171:174
PPTY
ITCH,NEDD4
0.9366
More...
Q86U70
LIM domain-binding protein 1
ITCH
49:52
PPTY
ITCH,NEDD4
0.9966
More...
O15165
Low-density lipoprotein receptor class A domain-containing protein 4
ITCH
252:255
PPTY
ITCH,NEDD4
0.9918
More...
Q92859
Neogenin
ITCH
1372:1375
PPTY
ITCH,NEDD4
0.9601
More...
Q92540
Nonsense-mediated mRNA decay factor SMG7
ITCH
666:669
PPTY
ITCH,NEDD4
0.8045
More...
P23760
Paired box protein Pax-3
ITCH
450:453
PPTY
ITCH,NEDD4
0.9541
More...
P23759
Paired box protein Pax-7
ITCH
444:447
PPTY
ITCH,NEDD4
0.9893
More...
O15357
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
ITCH
658:661
PPTY
ITCH,NEDD4
0.6551
More...
Q9UPA5
Protein bassoon
ITCH
1952:1955
PPTY
ITCH,NEDD4
0.8543
More...
A6NMK8
Protein INSYN2B
ITCH
76:79
PPTY
ITCH,NEDD4
0.8124
More...
Q5JSZ5
Protein PRRC2B
ITCH
275:278
PPTY
ITCH,NEDD4
0.8146
More...
Q969W9
Protein TMEPAI
ITCH
229:232
PPTY
ITCH,NEDD4
0.9995
More...
Showing 1 to 25 of 41 entries
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