DegronMD - Q969W9(PMEPA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P160L	TCGA-18-3409	LUSC	TCGA	PPPY	ITCH	158:161	Mutation altering degron motif	0.6471
p.Y239C	TCGA-39-5040	LUSC	TCGA	PPTY	ITCH	229:232	Mutation blocking phosphorylation signal	0.5833
p.E226K	TCGA-90-A4ED	LUSC	TCGA	PPTY	ITCH	229:232	Mutation rewiring degron network	0.25
p.G163D	TCGA-D9-A4Z3	SKCM	TCGA	PPPY	ITCH	158:161	Mutation rewiring degron network	0.2778
p.P160H	TCGA-DD-AACX	LIHC	TCGA	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.P160H	SIDM00094	Kidney Carcinoma	GDSC	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.P160H	ACH-002199	Kidney Cancer	CCLE	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.P160H	SN12C	kidney	COSMIC	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.R170W	TCGA-FI-A2D5	UCEC	TCGA	PPPY	ITCH	158:161	Mutation rewiring degron network	0.0833
p.P164L	TCGA-FR-A726	SKCM	TCGA	PPPY	ITCH	158:161	Mutation rewiring degron network	0.25
p.R224C	TCGA-IB-7651	PAAD	TCGA	PPTY	ITCH	229:232	Mutation rewiring degron network	0.1944
p.Y219N	TCGA-IB-7651	PAAD	TCGA	PPTY	ITCH	229:232	Mutation blocking phosphorylation signal	0.5
p.S151L	TCGA-IB-7651	PAAD	TCGA	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1389
p.G155A	TCGA-QB-A6FS	SKCM	TCGA	PPPY	ITCH	158:161	Mutation rewiring degron network	0.25
p.P240L	TCGA-VQ-A8P2	STAD	TCGA	PPTY	ITCH	229:232	Mutation rewiring degron network	0.1111
p.R224H	TCGA-XU-A92V	THYM	TCGA	PPTY	ITCH	229:232	Mutation rewiring degron network	0.1944
p.R224H	ACH-001333	Cervical Cancer	CCLE	PPTY	ITCH	229:232	Mutation rewiring degron network	0.1944
p.T229A	DO51948	BLCA	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.R151S	DO219037	BLCA	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1389
p.D158Y	DO219031	BLCA	ICGC	PPPY	ITCH	158:161	Mutation altering degron motif	0.7325
p.D148V	DO2149	BRCA	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.0556
p.A237T	DO230347	COCA	ICGC	PPTY	ITCH	229:232	Mutation rewiring degron network	0.1944
p.A237T	DO40978	UCEC	ICGC	PPTY	ITCH	229:232	Mutation rewiring degron network	0.1944
p.R149C	DO233168	GACA	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.0833
p.R149C	DO228223	LICA	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.0833
p.K229N	DO19500	KIRC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.6918
p.G153S	DO50955	LICA	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1944
p.C168F	DO23838	LUAD	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1389
p.L167R	DO23798	LUAD	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1667
p.G234R	DO23629	LUAD	ICGC	PPTY	ITCH	229:232	Mutation rewiring degron network	0.2778
p.Y169N	DO46657	PAAD	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1111
p.I156M	DO35603	PBCA	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.2778
p.G223R	DO37410	SKCM	ICGC	PPTY	ITCH	229:232	Mutation rewiring degron network	0.1667
p.A150T	DO222392	STAD	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1111
p.A166V	DO42568	UCEC	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1944
p.A232T	DO43891	UCEC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.A232T	DO42472	UCEC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.A232T	DO42665	UCEC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.L167I	SIDM01278	Colorectal Carcinoma	GDSC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.1667
p.E157D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.3056
p.E157D	ACH-000925	Lung Cancer	CCLE	PPPY	ITCH	158:161	Mutation rewiring degron network	0.3056
p.C165Y	ACH-000979	Prostate Cancer	CCLE	PPPY	ITCH	158:161	Mutation rewiring degron network	0.2222
p.P158T	ACH-001852	Bile Duct Cancer	CCLE	PPPY	ITCH	158:161	Mutation altering degron motif	0.7031
p.S159N	NB14	autonomic ganglia	COSMIC	PPPY	ITCH	158:161	Mutation altering degron motif	0.7069

Kaplan plot for PMEPA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PMEPA1

UniProt ID: Q969W9

Entrez ID: 56937

Protein name: Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PMEPA1 in