DegronMD - Q969W9(PMEPA1)

FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal tra... View more >>

GO - Biological processes (BP): androgen receptor signaling pathway [GO:0030521]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of SMAD protein complex assembly [GO:0010991]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]

GO - Molecular function (MF): R-SMAD binding [GO:0070412]; WW domain binding [GO:0050699]

GO - Cellular component (CC): early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D158Y	DO219031	BLCA	ICGC	PPPY	ITCH	158:161	Mutation altering degron motif	0.7325
p.T229A	DO51948	BLCA	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.A232T	DO43891	UCEC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.A232T	DO42472	UCEC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.A232T	DO42665	UCEC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.7139
p.S159N	NB14	autonomic ganglia	COSMIC	PPPY	ITCH	158:161	Mutation altering degron motif	0.7069
p.P158T	ACH-001852	Bile Duct Cancer	CCLE	PPPY	ITCH	158:161	Mutation altering degron motif	0.7031
p.K229N	DO19500	KIRC	ICGC	PPTY	ITCH	229:232	Mutation altering degron motif	0.6918
p.P160H	TCGA-DD-AACX	LIHC	TCGA	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.P160H	SIDM00094	Kidney Carcinoma	GDSC	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.P160H	ACH-002199	Kidney Cancer	CCLE	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.P160H	SN12C	kidney	COSMIC	PPPY	ITCH	158:161	Mutation altering degron motif	0.6583
p.P160L	TCGA-18-3409	LUSC	TCGA	PPPY	ITCH	158:161	Mutation altering degron motif	0.6471
p.Y239C	TCGA-39-5040	LUSC	TCGA	PPTY	ITCH	229:232	Mutation blocking phosphorylation signal	0.5833
p.Y219N	TCGA-IB-7651	PAAD	TCGA	PPTY	ITCH	229:232	Mutation blocking phosphorylation signal	0.5
p.E157D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.3056
p.E157D	ACH-000925	Lung Cancer	CCLE	PPPY	ITCH	158:161	Mutation rewiring degron network	0.3056
p.G163D	TCGA-D9-A4Z3	SKCM	TCGA	PPPY	ITCH	158:161	Mutation rewiring degron network	0.2778
p.G234R	DO23629	LUAD	ICGC	PPTY	ITCH	229:232	Mutation rewiring degron network	0.2778
p.I156M	DO35603	PBCA	ICGC	PPPY	ITCH	158:161	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 44 entries

Previous1 2 3Next

Kaplan plot for PMEPA1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PMEPA1

UniProt ID: Q969W9

Entrez ID: 56937

Protein name: Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PMEPA1 in