DegronMD

Uniprot ID: Q969W9

Source protein: Protein TMEPAI

Source gene: PMEPA1

Class: ITCH

Location: 158:161

E3 ligase: ITCH,NEDD4

DEGRON score: 0.866

ASA_SCORE: 70.575

COIL: 0.8903

CONS_SCORE: 0.8423

DSS_SCORE: 0.6907

HELIX: 0.0488

FCONS_SCORE: 0.9142

RIG_SCORE: 0.6044

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D158Y	DO219031	BLCA	ICGC	PPPY	ITCH	0.7325
p.S159N	NB14	autonomic_ganglia	COSMIC	PPPY	ITCH	0.7069
p.P158T	ACH-001852	Bile Duct Cancer	CCLE	PPPY	ITCH	0.7031
p.P160H	TCGA-DD-AACX	LIHC	TCGA	PPPY	ITCH	0.6583
p.P160H	SIDM00094	Kidney Carcinoma	GDSC	PPPY	ITCH	0.6583
p.P160H	ACH-002199	Kidney Cancer	CCLE	PPPY	ITCH	0.6583
p.P160H	SN12C	kidney	COSMIC	PPPY	ITCH	0.6583
p.P160L	TCGA-18-3409	LUSC	TCGA	PPPY	ITCH	0.6471
p.E157D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	0.3056
p.E157D	ACH-000925	Lung Cancer	CCLE	PPPY	ITCH	0.3056
p.G163D	TCGA-D9-A4Z3	SKCM	TCGA	PPPY	ITCH	0.2778
p.I156M	DO35603	PBCA	ICGC	PPPY	ITCH	0.2778
p.P164L	TCGA-FR-A726	SKCM	TCGA	PPPY	ITCH	0.25
p.G155A	TCGA-QB-A6FS	SKCM	TCGA	PPPY	ITCH	0.25
p.C165Y	ACH-000979	Prostate Cancer	CCLE	PPPY	ITCH	0.2222
p.G153S	DO50955	LICA	ICGC	PPPY	ITCH	0.1944
p.A166V	DO42568	UCEC	ICGC	PPPY	ITCH	0.1944
p.L167R	DO23798	LUAD	ICGC	PPPY	ITCH	0.1667
p.L167I	SIDM01278	Colorectal Carcinoma	GDSC	PPPY	ITCH	0.1667
p.S151L	TCGA-IB-7651	PAAD	TCGA	PPPY	ITCH	0.1389
p.R151S	DO219037	BLCA	ICGC	PPPY	ITCH	0.1389
p.C168F	DO23838	LUAD	ICGC	PPPY	ITCH	0.1389
p.Y169N	DO46657	PAAD	ICGC	PPPY	ITCH	0.1111
p.A150T	DO222392	STAD	ICGC	PPPY	ITCH	0.1111
p.R170W	TCGA-FI-A2D5	UCEC	TCGA	PPPY	ITCH	0.0833

Showing 1 to 25 of 28 entries

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Drug responses associated with PMEPA1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPPY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DV4	39S ribosomal protein L38, mitochondrial	ITCH	347:350	PPPY	ITCH,NEDD4	0.6466	More...
O15072	A disintegrin and metalloproteinase with thrombospondin motifs 3	ITCH	1058:1061	PPPY	ITCH,NEDD4	0.9797	More...
Q13625	Apoptosis-stimulating of p53 protein 2	ITCH	871:874	PPPY	ITCH,NEDD4	0.9885	More...
P54259	Atrophin-1	ITCH	445:448	PPPY	ITCH,NEDD4	0.973	More...
P54259	Atrophin-1	ITCH	636:639	PPPY	ITCH,NEDD4	0.9909	More...
Q8WXX7	Autism susceptibility gene 2 protein	ITCH	516:519	PPPY	ITCH,NEDD4	0.9979	More...
O00512	B-cell CLL/lymphoma 9 protein	ITCH	515:518	PPPY	ITCH,NEDD4	0.9973	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	ITCH	561:564	PPPY	ITCH,NEDD4	0.9923	More...
O95395	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	ITCH	285:288	PPPY	ITCH,NEDD4	0.5532	More...
O95415	Brain protein I3	ITCH	39:42	PPPY	ITCH,NEDD4	0.9496	More...
Q15018	BRISC complex subunit Abraxas 2	ITCH	305:308	PPPY	ITCH,NEDD4	0.9939	More...
Q9P203	BTB/POZ domain-containing protein 7	ITCH	762:765	PPPY	ITCH,NEDD4	0.9575	More...
Q9Y6W3	Calpain-7	ITCH	624:627	PPPY	ITCH,NEDD4	0.5393	More...
Q8WXE0	Caskin-2	ITCH	751:754	PPPY	ITCH,NEDD4	0.6879	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9945	More...
Q9H305	Cell death-inducing p53-target protein 1	ITCH	51:54	PPPY	ITCH,NEDD4	0.9943	More...
Q16630	Cleavage and polyadenylation specificity factor subunit 6	ITCH	387:390	PPPY	ITCH,NEDD4	0.9919	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	ITCH	704:707	PPPY	ITCH,NEDD4	0.9478	More...
Q86YQ8	Copine-8	ITCH	550:553	PPPY	ITCH,NEDD4	0.743	More...
Q6UUV7	CREB-regulated transcription coactivator 3	ITCH	445:448	PPPY	ITCH,NEDD4	0.998	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	113:116	PPPY	ITCH,NEDD4	0.9396	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	129:132	PPPY	ITCH,NEDD4	0.9428	More...
Q96J86	Cysteine and tyrosine-rich protein 1	ITCH	145:148	PPPY	ITCH,NEDD4	0.9794	More...
Q9H1C7	Cysteine-rich and transmembrane domain-containing protein 1	ITCH	6:9	PPPY	ITCH,NEDD4	0.9391	More...
Q9BTC0	Death-inducer obliterator 1	ITCH	1817:1820	PPPY	ITCH,NEDD4	0.9967	More...

Showing 1 to 25 of 180 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPPY

Degron related mutations and impact score

Drug responses associated with PMEPA1 mutations

All proteins holding degron of PPPY