DegronMD - Q8TB68(PRR7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R178H	TCGA-CN-6997	HNSC	TCGA	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.2778
p.R178H	DO14414	HNSC	ICGC	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.2778
p.E168K	TCGA-T2-A6X2	HNSC	TCGA	PPPY	ITCH	163:166	Mutation rewiring degron network	0.2778
p.E168K	DO219071	HNSC	ICGC	PPPY	ITCH	163:166	Mutation rewiring degron network	0.2778
p.E195K	TCGA-XF-A9T0	BLCA	TCGA	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.0833
p.E195K	TCGA-XF-A9T0	BLCA	TCGA	PPSY	ITCH	198:201	Mutation rewiring degron network	0.25
p.E195K	DO51920	BLCA	ICGC	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.0833
p.E195K	DO51920	BLCA	ICGC	PPSY	ITCH	198:201	Mutation rewiring degron network	0.25
p.V181G	DO233935	GACA	ICGC	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.6421
p.R208L	DO228976	LICA	ICGC	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1389
p.S186C	DO229250	THCA	ICGC	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation altering degron motif	0.7541
p.A191E	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1944
p.A191E	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1389
p.A191E	ACH-000980	Lung Cancer	CCLE	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1944
p.A191E	ACH-000980	Lung Cancer	CCLE	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1389
p.A191E	NCI-H1155	lung	COSMIC	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1944
p.A191E	NCI-H1155	lung	COSMIC	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1389
p.A191T	SIDM01617	Endometrial Carcinoma	GDSC	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1944
p.A191T	SIDM01617	Endometrial Carcinoma	GDSC	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1389
p.A191T	ACH-000994	Endometrial/Uterine Cancer	CCLE	IVTPFLS	DEG_SCF_FBW7_1	180:186	Mutation rewiring degron network	0.1944
p.A191T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1389
p.G209S	SIDM01435	Hepatocellular Carcinoma	GDSC	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1111
p.G209S	ACH-000686	Liver Cancer	CCLE	PPSY	ITCH	198:201	Mutation rewiring degron network	0.1111

Kaplan plot for PRR7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR7

UniProt ID: Q8TB68

Entrez ID: 80758

Protein name: Proline-rich protein 7 (Synaptic proline-rich membrane protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PRR7 in