DegronMD

Uniprot ID: Q8TB68

Source protein: Proline-rich protein 7

Source gene: PRR7

Class: DEG_SCF_FBW7_1

Location: 180:186

E3 ligase: FBXW7

DEGRON score: 0.9856

ASA_SCORE: 65.1714

COIL: 0.764

CONS_SCORE: 0.7249

DSS_SCORE: 0.422

HELIX: 0.1671

FCONS_SCORE: 0.9134

RIG_SCORE: 0.8081

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S186C	DO229250	THCA	ICGC	IVTPFLS	DEG_SCF_FBW7_1	0.7541
p.V181G	DO233935	GACA	ICGC	IVTPFLS	DEG_SCF_FBW7_1	0.6421
p.R178H	TCGA-CN-6997	HNSC	TCGA	IVTPFLS	DEG_SCF_FBW7_1	0.2778
p.R178H	DO14414	HNSC	ICGC	IVTPFLS	DEG_SCF_FBW7_1	0.2778
p.A191E	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	IVTPFLS	DEG_SCF_FBW7_1	0.1944
p.A191E	ACH-000980	Lung Cancer	CCLE	IVTPFLS	DEG_SCF_FBW7_1	0.1944
p.A191E	NCI-H1155	lung	COSMIC	IVTPFLS	DEG_SCF_FBW7_1	0.1944
p.A191T	SIDM01617	Endometrial Carcinoma	GDSC	IVTPFLS	DEG_SCF_FBW7_1	0.1944
p.A191T	ACH-000994	Endometrial/Uterine Cancer	CCLE	IVTPFLS	DEG_SCF_FBW7_1	0.1944
p.E195K	TCGA-XF-A9T0	BLCA	TCGA	IVTPFLS	DEG_SCF_FBW7_1	0.0833
p.E195K	DO51920	BLCA	ICGC	IVTPFLS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TB68	Proline-rich protein 7	DEG_SCF_FBW7_1	180:186	IVTPFLS	FBXW7	0.9856	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons