DegronMD - Q13635(PTCH1)

GO - Biological processes (BP): animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation involved in kidney development [GO:0061005]; cell fate determination [GO:0001709]; cell proliferation involved in metanephros development [GO:0072203]; cellular response to cholesterol [GO:0071397]; commissural neuron axon guidance [GO:0071679]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; epidermal cell fate specification [GO:0009957]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; hindlimb morphogenesis [GO:0035137]; in utero embryonic development [GO:0001701]; keratinocyte proliferation [GO:0043616]; limb morphogenesis [GO:0035108]; liver regeneration [GO:0097421]; mammary gland duct morphogenesis [GO:0060603]; mammary gland epithelial cell differentiation [GO:0060644]; metanephric collecting duct development [GO:0072205]; negative regulation of cell division [GO:0051782]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube closure [GO:0001843]; neural tube patterning [GO:0021532]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of transcription, DNA-templated [GO:0045893]; prostate gland development [GO:0030850]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; response to chlorate [GO:0010157]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; smooth muscle tissue development [GO:0048745]; somite development [GO:0061053]; spinal cord motor neuron differentiation [GO:0021522] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1173M	TCGA-A5-A0G1	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.1944
p.V1173M	TCGA-DU-6392	LGG	TCGA	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.1944
p.R1192H	TCGA-AP-A1DM	UCEC	TCGA	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.3056
p.R1192H	TCGA-AP-A1DM	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.0833
p.R1192H	TCGA-AX-A2HD	UCEC	TCGA	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.3056
p.R1192H	TCGA-AX-A2HD	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.0833
p.P1180Q	TCGA-AZ-4681	COAD	TCGA	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation altering degron motif	0.7035
p.D635G	TCGA-BG-A222	UCEC	TCGA	DNTRYSPPP	CBL_PTK	635:643	Mutation altering degron motif	0.7198
p.T693A	TCGA-BR-6452	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.F1177L	TCGA-BS-A0UV	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.3056
p.E703K	TCGA-CK-4951	COAD	TCGA	PESTS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.591
p.L697I	TCGA-D5-6530	COAD	TCGA	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1944
p.Y639H	TCGA-EI-6882	READ	TCGA	DNTRYSPPP	CBL_PTK	635:643	Mutation altering degron motif	0.7229
p.R1320K	TCGA-FD-A3SS	BLCA	TCGA	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.2222
p.P1182H	TCGA-IB-7651	PAAD	TCGA	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation altering degron motif	0.6583
p.P1318L	TCGA-L5-A4OI	ESCA	TCGA	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.2778
p.H648D	TCGA-MP-A4SY	LUAD	TCGA	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.1944
p.P1313S	TCGA-NH-A5IV	COAD	TCGA	PPPY	ITCH	1313:1316	Mutation altering degron motif	0.6752
p.S698I	TCGA-VQ-A8PP	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2222
p.P1323H	DO49929	CESC	ICGC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.1389
p.H1316Y	DO49095	COAD	ICGC	PPPY	ITCH	1313:1316	Mutation altering degron motif	0.7229
p.E637K	DO10582	COAD	ICGC	DNTRYSPPP	CBL_PTK	635:643	Mutation altering degron motif	0.7022
p.T1306M	DO223703	COAD	ICGC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.1389
p.L631I	DO8312	COAD	ICGC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.2222
p.R1325Q	DO222765	COCA	ICGC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.0833
p.R1325Q	DO45299	LIRI	ICGC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.0833
p.Q1187P	DO52453	COCA	ICGC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1667
p.Q1187P	DO52453	COCA	ICGC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.2222
p.P716T	DO233081	GACA	ICGC	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0556
p.V1204A	DO233737	GACA	ICGC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1944
p.R1325W	DO233823	GACA	ICGC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.0833
p.G693R	DO14630	HNSC	ICGC	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.G696E	DO228667	LICA	ICGC	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1667
p.Q1187K	DO229027	LICA	ICGC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1667
p.Q1187K	DO229027	LICA	ICGC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.2222
p.A1177D	DO229037	LICA	ICGC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.3056
p.H1174N	DO229041	LICA	ICGC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.2222
p.A1314S	DO231189	LUSC	ICGC	PPPY	ITCH	1313:1316	Mutation altering degron motif	0.7588
p.D651Y	DO51087	PRAD	ICGC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.1111
p.A1181V	DO36675	READ	ICGC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation altering degron motif	0.6936
p.T625I	DO47569	SKCM	ICGC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.0556
p.T627A	DO38404	STAD	ICGC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.1111
p.S632I	DO51774	STAD	ICGC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.25
p.P1319S	DO47745	STAD	ICGC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.25
p.R704Q	DO42320	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7329
p.R1173W	DO223286	UCEC	ICGC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.1944
p.V1203A	DO52402	UCEC	ICGC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.2222
p.E1207K	DO41758	UCEC	ICGC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1111
p.Y700H	DO42977	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2778
p.D651E	DO41584	UCEC	ICGC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.1111
p.V1315M	DO42761	UCEC	ICGC	PPPY	ITCH	1313:1316	Mutation altering degron motif	0.7208
p.Y1316C	SIDM00620	Glioblastoma	GDSC	PPPY	ITCH	1313:1316	Mutation altering degron motif	0.7087
p.Y1316C	SIDM00935	Other Solid Cancers	GDSC	PPPY	ITCH	1313:1316	Mutation altering degron motif	0.7087
p.Y1316C	SIDM01078	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	1313:1316	Mutation altering degron motif	0.7087
p.W1312R	SIDM00845	Burkitt's Lymphoma	GDSC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.3056
p.W1312R	SIDM00461	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.3056
p.W1312R	ACH-000786	Lymphoma	CCLE	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.3056
p.R1303H	SIDM00496	Thyroid Gland Carcinoma	GDSC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.0556
p.R1303H	HTC-C3	thyroid	COSMIC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.0556
p.P1180A	SIDM00643	Non-Cancerous	GDSC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation altering degron motif	0.7503
p.P1180A	ACH-000327	Lung Cancer	CCLE	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation altering degron motif	0.7503
p.P1180A	ACH-002363	Non-Cancerous	CCLE	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation altering degron motif	0.7503
p.R1320I	SIDM00941	Kidney Carcinoma	GDSC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.2222
p.R1320I	ACH-000433	Kidney Cancer	CCLE	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.2222
p.R1320I	CAKI-1	kidney	COSMIC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.2222
p.R1303C	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.0556
p.R1303C	KNS-62	lung	COSMIC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.0556
p.V625I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.0556
p.V625I	ACH-000945	Lung Cancer	CCLE	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.0556
p.V625I	NCI-H650	lung	COSMIC	DNTRYSPPP	CBL_PTK	635:643	Mutation rewiring degron network	0.0556
p.R1206C	SIDM01398	Melanoma	GDSC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1389
p.R1206C	ACH-000661	Skin Cancer	CCLE	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1389
p.M1209T	ACH-000998	Colon/Colorectal Cancer	CCLE	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.0556
p.R1169I	CAKI-1	kidney	COSMIC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.0833
p.D699G	GP5d	large intestine	COSMIC	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.25
p.A1202T	Daudi	haematopoietic and lymphoid tissue	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.25
p.T1204P	TE-4	oesophagus	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1944
p.N1184K	RS4-11	haematopoietic and lymphoid tissue	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.0833
p.N1184K	RS4-11	haematopoietic and lymphoid tissue	COSMIC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.3056
p.R1187H	HCC1569	breast	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.1667
p.R1187H	HCC1569	breast	COSMIC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.2222
p.G1192E	SNU-175	large intestine	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	1193:1199	Mutation rewiring degron network	0.3056
p.G1192E	SNU-175	large intestine	COSMIC	FGPYPE	LIG_APCC_ABBA_1	1178:1183	Mutation rewiring degron network	0.0833
p.S698G	NCI-H720	lung	COSMIC	PESTS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.2222
p.A1309G	SW684	soft tissue	COSMIC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.2222
p.R1319I	CAKI-1	kidney	COSMIC	PPPY	ITCH	1313:1316	Mutation rewiring degron network	0.25

Kaplan plot for PTCH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTCH1

UniProt ID: Q13635

Entrez ID: 5727

Protein name: Protein patched homolog 1 (PTC) (PTC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTCH1 in