DegronMD

Uniprot ID: Q13635

Source protein: Protein patched homolog 1

Source gene: PTCH1

Class: DEG_SCF_FBW7_2

Location: 1193:1199

E3 ligase: FBXW7

DEGRON score: 0.5527

ASA_SCORE: 99.5143

COIL: 0.9571

CONS_SCORE: 0.303

DSS_SCORE: 0.5953

HELIX: 0.0081

FCONS_SCORE: 0.9851

RIG_SCORE: 0.5809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1192H	TCGA-AP-A1DM	UCEC	TCGA	LPTPSPE	DEG_SCF_FBW7_2	0.3056
p.R1192H	TCGA-AX-A2HD	UCEC	TCGA	LPTPSPE	DEG_SCF_FBW7_2	0.3056
p.Q1187P	DO52453	COCA	ICGC	LPTPSPE	DEG_SCF_FBW7_2	0.1667
p.V1204A	DO233737	GACA	ICGC	LPTPSPE	DEG_SCF_FBW7_2	0.1944
p.Q1187K	DO229027	LICA	ICGC	LPTPSPE	DEG_SCF_FBW7_2	0.1667
p.V1203A	DO52402	UCEC	ICGC	LPTPSPE	DEG_SCF_FBW7_2	0.2222
p.E1207K	DO41758	UCEC	ICGC	LPTPSPE	DEG_SCF_FBW7_2	0.1111
p.R1206C	SIDM01398	Melanoma	GDSC	LPTPSPE	DEG_SCF_FBW7_2	0.1389
p.R1206C	ACH-000661	Skin Cancer	CCLE	LPTPSPE	DEG_SCF_FBW7_2	0.1389
p.M1209T	ACH-000998	Colon/Colorectal Cancer	CCLE	LPTPSPE	DEG_SCF_FBW7_2	0.0556
p.A1202T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	0.25
p.T1204P	TE-4	oesophagus	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	0.1944
p.N1184K	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	0.0833
p.R1187H	HCC1569	breast	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	0.1667
p.G1192E	SNU-175	large_intestine	COSMIC	LPTPSPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CG30	Glutathione S-transferase theta-2B	DEG_SCF_FBW7_2	225:231	LPTPSPE	FBXW7	0.9414	More...
Q13635	Protein patched homolog 1	DEG_SCF_FBW7_2	1193:1199	LPTPSPE	FBXW7	0.5527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons