DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LPTPSPE
Uniprot ID:
P0CG30
Source protein:
Glutathione S-transferase theta-2B
Source gene:
GSTT2B
Class:
DEG_SCF_FBW7_2
Location:
225:231
E3 ligase:
FBXW7
DEGRON score:
0.9414
ASA_SCORE:
81.3714
COIL:
0.7371
CONS_SCORE:
0.4296
DSS_SCORE:
0.2996
HELIX:
0.255
FCONS_SCORE:
1.1697
RIG_SCORE:
0.7128
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GSTT2B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPTPSPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0CG30
Glutathione S-transferase theta-2B
DEG_SCF_FBW7_2
225:231
LPTPSPE
FBXW7
0.9414
More...
Q13635
Protein patched homolog 1
DEG_SCF_FBW7_2
1193:1199
LPTPSPE
FBXW7
0.5527
More...