DegronMD

Uniprot ID: Q13635

Source protein: Protein patched homolog 1

Source gene: PTCH1

Class: CBL_PTK

Location: 635:643

E3 ligase: CBL

DEGRON score: 0.5315

ASA_SCORE: 76.2

COIL: 0.8732

CONS_SCORE: 0.277

DSS_SCORE: 0.6372

HELIX: 0.0302

FCONS_SCORE: 0.9735

RIG_SCORE: 0.6352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D635G	TCGA-BG-A222	UCEC	TCGA	DNTRYSPPP	CBL_PTK	0.7198
p.Y639H	TCGA-EI-6882	READ	TCGA	DNTRYSPPP	CBL_PTK	0.7229
p.H648D	TCGA-MP-A4SY	LUAD	TCGA	DNTRYSPPP	CBL_PTK	0.1944
p.E637K	DO10582	COAD	ICGC	DNTRYSPPP	CBL_PTK	0.7022
p.L631I	DO8312	COAD	ICGC	DNTRYSPPP	CBL_PTK	0.2222
p.D651Y	DO51087	PRAD	ICGC	DNTRYSPPP	CBL_PTK	0.1111
p.T625I	DO47569	SKCM	ICGC	DNTRYSPPP	CBL_PTK	0.0556
p.T627A	DO38404	STAD	ICGC	DNTRYSPPP	CBL_PTK	0.1111
p.S632I	DO51774	STAD	ICGC	DNTRYSPPP	CBL_PTK	0.25
p.D651E	DO41584	UCEC	ICGC	DNTRYSPPP	CBL_PTK	0.1111
p.V625I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	DNTRYSPPP	CBL_PTK	0.0556
p.V625I	ACH-000945	Lung Cancer	CCLE	DNTRYSPPP	CBL_PTK	0.0556
p.V625I	NCI-H650	lung	COSMIC	DNTRYSPPP	CBL_PTK	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13635	Protein patched homolog 1	CBL_PTK	635:643	DNTRYSPPP	CBL	0.5315	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons