DegronMD

Uniprot ID: Q13635

Source protein: Protein patched homolog 1

Source gene: PTCH1

Class: LIG_APCC_ABBA_1

Location: 1178:1183

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9172

ASA_SCORE: 68.5167

COIL: 0.8112

CONS_SCORE: 0.5752

DSS_SCORE: 0.0367

HELIX: 0.1417

FCONS_SCORE: 1.1971

RIG_SCORE: 0.7678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1173M	TCGA-A5-A0G1	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.1944
p.V1173M	TCGA-DU-6392	LGG	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.1944
p.R1192H	TCGA-AP-A1DM	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.0833
p.R1192H	TCGA-AX-A2HD	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.0833
p.P1180Q	TCGA-AZ-4681	COAD	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.7035
p.F1177L	TCGA-BS-A0UV	UCEC	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.3056
p.P1182H	TCGA-IB-7651	PAAD	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.6583
p.Q1187P	DO52453	COCA	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.2222
p.Q1187K	DO229027	LICA	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.2222
p.A1177D	DO229037	LICA	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.3056
p.H1174N	DO229041	LICA	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.2222
p.A1181V	DO36675	READ	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.6936
p.R1173W	DO223286	UCEC	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.1944
p.P1180A	SIDM00643	Non-Cancerous	GDSC	FGPYPE	LIG_APCC_ABBA_1	0.7503
p.P1180A	ACH-000327	Lung Cancer	CCLE	FGPYPE	LIG_APCC_ABBA_1	0.7503
p.P1180A	ACH-002363	Non-Cancerous	CCLE	FGPYPE	LIG_APCC_ABBA_1	0.7503
p.R1169I	CAKI-1	kidney	COSMIC	FGPYPE	LIG_APCC_ABBA_1	0.0833
p.N1184K	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	FGPYPE	LIG_APCC_ABBA_1	0.3056
p.R1187H	HCC1569	breast	COSMIC	FGPYPE	LIG_APCC_ABBA_1	0.2222
p.G1192E	SNU-175	large_intestine	COSMIC	FGPYPE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13635	Protein patched homolog 1	LIG_APCC_ABBA_1	1178:1183	FGPYPE	APC,CDC20,FZR1	0.9172	More...
Q96M69	Leucine-rich repeat and guanylate kinase domain-containing protein	LIG_APCC_ABBA_1	726:731	FGPYPE	APC,CDC20,FZR1	0.6998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons