DegronMD - Q96M69(LRGUK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G727E	TCGA-77-8009	LUSC	TCGA	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.6087
p.G727E	DO27200	LUSC	ICGC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.6087
p.L717F	TCGA-BF-AAP2	SKCM	TCGA	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0833
p.L717F	DO219466	SKCM	ICGC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0833
p.E731G	TCGA-CG-4462	STAD	TCGA	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.7199
p.E731G	DO38292	STAD	ICGC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.7199
p.S737F	TCGA-D3-A2JF	SKCM	TCGA	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1667
p.S737F	DO38153	SKCM	ICGC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.1667
p.E731K	DO225046	BRCA	ICGC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation altering degron motif	0.7022
p.K732N	DO222798	COCA	ICGC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.3056
p.M741T	SIDM00592	Oral Cavity Carcinoma	GDSC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0556
p.M741T	ACH-002244	Head and Neck Cancer	CCLE	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0556
p.M741T	HO-1-N-1	salivary gland	COSMIC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0556
p.S740F	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.0833
p.P725A	SIDM01448	Head and Neck Carcinoma	GDSC	FGPYPE	LIG_APCC_ABBA_1	726:731	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons