DegronMD

Uniprot ID: Q96M69

Source protein: Leucine-rich repeat and guanylate kinase domain-containing protein

Source gene: LRGUK

Class: LIG_APCC_ABBA_1

Location: 726:731

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6998

ASA_SCORE: 90.3333

COIL: 0.9475

CONS_SCORE: 0.3257

DSS_SCORE: 0.2924

HELIX: 0.0253

FCONS_SCORE: 1.0601

RIG_SCORE: 0.7228

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G727E	TCGA-77-8009	LUSC	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.6087
p.G727E	DO27200	LUSC	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.6087
p.L717F	TCGA-BF-AAP2	SKCM	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.0833
p.L717F	DO219466	SKCM	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.0833
p.E731G	TCGA-CG-4462	STAD	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.7199
p.E731G	DO38292	STAD	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.7199
p.S737F	TCGA-D3-A2JF	SKCM	TCGA	FGPYPE	LIG_APCC_ABBA_1	0.1667
p.S737F	DO38153	SKCM	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.1667
p.E731K	DO225046	BRCA	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.7022
p.K732N	DO222798	COCA	ICGC	FGPYPE	LIG_APCC_ABBA_1	0.3056
p.M741T	SIDM00592	Oral Cavity Carcinoma	GDSC	FGPYPE	LIG_APCC_ABBA_1	0.0556
p.M741T	ACH-002244	Head and Neck Cancer	CCLE	FGPYPE	LIG_APCC_ABBA_1	0.0556
p.M741T	HO-1-N-1	salivary_gland	COSMIC	FGPYPE	LIG_APCC_ABBA_1	0.0556
p.S740F	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	FGPYPE	LIG_APCC_ABBA_1	0.0833
p.P725A	SIDM01448	Head and Neck Carcinoma	GDSC	FGPYPE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13635	Protein patched homolog 1	LIG_APCC_ABBA_1	1178:1183	FGPYPE	APC,CDC20,FZR1	0.9172	More...
Q96M69	Leucine-rich repeat and guanylate kinase domain-containing protein	LIG_APCC_ABBA_1	726:731	FGPYPE	APC,CDC20,FZR1	0.6998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons