DegronMD

Uniprot ID: Q13635

Source protein: Protein patched homolog 1

Source gene: PTCH1

Class: DEG_SPOP_SBC_1

Location: 702:706

E3 ligase: SPOP

DEGRON score: 0.5289

ASA_SCORE: 71.96

COIL: 0.8116

CONS_SCORE: 0.3144

DSS_SCORE: 0.486

HELIX: 0.1274

FCONS_SCORE: 1.1383

RIG_SCORE: 0.6443

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T693A	TCGA-BR-6452	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.0833
p.E703K	TCGA-CK-4951	COAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.591
p.L697I	TCGA-D5-6530	COAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.1944
p.S698I	TCGA-VQ-A8PP	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.2222
p.P716T	DO233081	GACA	ICGC	PESTS	DEG_SPOP_SBC_1	0.0556
p.G693R	DO14630	HNSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.0833
p.G696E	DO228667	LICA	ICGC	PESTS	DEG_SPOP_SBC_1	0.1667
p.R704Q	DO42320	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	0.7329
p.Y700H	DO42977	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.D699G	GP5d	large_intestine	COSMIC	PESTS	DEG_SPOP_SBC_1	0.25
p.S698G	NCI-H720	lung	COSMIC	PESTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons