DegronMD

Uniprot ID: C9JH25

Source protein: Proline-rich transmembrane protein 4

Source gene: PRRT4

Class: DEG_SPOP_SBC_1

Location: 129:133

E3 ligase: SPOP

DEGRON score: 0.9849

ASA_SCORE: 81.78

COIL: 0.895

CONS_SCORE: 0.8155

DSS_SCORE: 0.7246

HELIX: 0.0772

FCONS_SCORE: 1.0883

RIG_SCORE: 0.5979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P129L	TCGA-2W-A8YY	CESC	TCGA	PESTS	DEG_SPOP_SBC_1	0.7582
p.P129L	DO223732	CESC	ICGC	PESTS	DEG_SPOP_SBC_1	0.7582
p.S125P	TCGA-AP-A1DK	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	0.2222
p.S125P	DO42033	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2222
p.R123W	TCGA-AZ-6601	COAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.1667
p.R123W	DO8119	COAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.1667
p.R123Q	TCGA-BG-A18B	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	0.1667
p.R123Q	TCGA-KH-A6WC	ESCA	TCGA	PESTS	DEG_SPOP_SBC_1	0.1667
p.R123Q	DO41452	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	0.1667
p.R123Q	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.1667
p.R123Q	ACH-000747	Lung Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.1667
p.R135C	DO230336	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.R134Q	DO229013	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.R134Q	DO229016	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.R134Q	DO230659	LAML	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.R134Q	DO231106	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.R134Q	DO231141	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.R135H	SIDM01307	Colorectal Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons