DegronMD - Q9BT25(HAUS8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S131A	TCGA-12-3651	GBM	TCGA	PESTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.87
p.T122A	TCGA-17-Z033	LUAD	TCGA	PESTS	DEG_SPOP_SBC_1	127:131	Mutation blocking phosphorylation signal	0.6389
p.P140L	TCGA-2W-A8YY	CESC	TCGA	PESTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.P117Q	TCGA-78-7535	LUAD	TCGA	PESTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.P372L	TCGA-AD-6899	COAD	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.2222
p.P372L	SIDM00672	Hepatocellular Carcinoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.2222
p.P372L	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.2222
p.P372L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.2222
p.S367F	TCGA-BF-A1Q0	SKCM	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation altering degron motif	0.6871
p.S124L	TCGA-CQ-5331	HNSC	TCGA	PESTS	DEG_SPOP_SBC_1	127:131	Mutation blocking phosphorylation signal	0.6944
p.T364M	TCGA-EY-A549	UCEC	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation altering degron motif	0.7423
p.T364M	SIDM01126	Small Cell Lung Carcinoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation altering degron motif	0.7423
p.T364M	SIDM01164	Glioma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation altering degron motif	0.7423
p.E356K	TCGA-KQ-A41R	BLCA	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.1944
p.E355K	DO223592	BLCA	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.1667
p.P139L	DO223732	CESC	ICGC	PESTS	DEG_SPOP_SBC_1	127:131	Mutation blocking phosphorylation signal	0.5556
p.P371L	DO8818	COAD	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.25
p.S130A	DO13845	GBM	ICGC	PESTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7588
p.S123L	DO15495	HNSC	ICGC	PESTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.N370K	DO228976	LICA	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.2778
p.R135Q	DO231596	LINC	ICGC	PESTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.S366F	DO47374	SKCM	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation altering degron motif	0.7982
p.T363M	DO48174	UCEC	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation altering degron motif	0.7423
p.A378T	DO42665	UCEC	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.0556
p.S375L	SIDM00330	Neuroblastoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.1389
p.S375L	ACH-001355	Neuroblastoma	CCLE	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.1389
p.S375L	LAN-6	autonomic ganglia	COSMIC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.1389
p.S131L	ACH-001694	Head and Neck Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.8778
p.C121F	CAPAN-1	pancreas	COSMIC	PESTS	DEG_SPOP_SBC_1	127:131	Mutation substituting flanking lysine	0.2778
p.K122E	HSC-2	upper aerodigestive tract	COSMIC	PESTS	DEG_SPOP_SBC_1	127:131	Mutation blocking phosphorylation signal	0.6389
p.S374L	LAN-6	autonomic ganglia	COSMIC	PKNTPLSE	DEG_SCF_FBW7_2	361:368	Mutation rewiring degron network	0.1667
p.S141F	JHH-7	liver	COSMIC	PESTS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556

Kaplan plot for HAUS8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HAUS8

UniProt ID: Q9BT25

Entrez ID: 93323

Protein name: HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HAUS8 in