DegronMD

Uniprot ID: Q9BT25

Source protein: HAUS augmin-like complex subunit 8

Source gene: HAUS8

Class: DEG_SCF_FBW7_2

Location: 361:368

E3 ligase: FBXW7

DEGRON score: 0.9146

ASA_SCORE: 84.3625

COIL: 0.8861

CONS_SCORE: 0.1872

DSS_SCORE: 0.7362

HELIX: 0.0371

FCONS_SCORE: 1.0056

RIG_SCORE: 0.6001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P372L	TCGA-AD-6899	COAD	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	0.2222
p.P372L	SIDM00672	Hepatocellular Carcinoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	0.2222
p.P372L	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	0.2222
p.P372L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	0.2222
p.S367F	TCGA-BF-A1Q0	SKCM	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	0.6871
p.T364M	TCGA-EY-A549	UCEC	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	0.7423
p.T364M	SIDM01126	Small Cell Lung Carcinoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	0.7423
p.T364M	SIDM01164	Glioma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	0.7423
p.E356K	TCGA-KQ-A41R	BLCA	TCGA	PKNTPLSE	DEG_SCF_FBW7_2	0.1944
p.E355K	DO223592	BLCA	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	0.1667
p.P371L	DO8818	COAD	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	0.25
p.N370K	DO228976	LICA	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	0.2778
p.S366F	DO47374	SKCM	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	0.7982
p.T363M	DO48174	UCEC	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	0.7423
p.A378T	DO42665	UCEC	ICGC	PKNTPLSE	DEG_SCF_FBW7_2	0.0556
p.S375L	SIDM00330	Neuroblastoma	GDSC	PKNTPLSE	DEG_SCF_FBW7_2	0.1389
p.S375L	ACH-001355	Neuroblastoma	CCLE	PKNTPLSE	DEG_SCF_FBW7_2	0.1389
p.S375L	LAN-6	autonomic_ganglia	COSMIC	PKNTPLSE	DEG_SCF_FBW7_2	0.1389
p.S374L	LAN-6	autonomic_ganglia	COSMIC	PKNTPLSE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SCF_FBW7_2	361:368	PKNTPLSE	FBXW7	0.9146	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons