DegronMD

Uniprot ID: P63252

Source protein: Inward rectifier potassium channel 2

Source gene: KCNJ2

Class: DEG_SPOP_SBC_1

Location: 395:399

E3 ligase: SPOP

DEGRON score: 0.5469

ASA_SCORE: 98.08

COIL: 0.9514

CONS_SCORE: 0.3689

DSS_SCORE: 0.8467

HELIX: 0.0244

FCONS_SCORE: 0.954

RIG_SCORE: 0.5725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T402R	TCGA-05-4427	LUAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.25
p.T402R	DO23666	LUAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.25
p.P404S	TCGA-90-A4ED	LUSC	TCGA	PESTS	DEG_SPOP_SBC_1	0.1944
p.P404S	DO45482	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.1944
p.S390C	TCGA-95-7039	LUAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.1944
p.S390C	DO23907	LUAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.1944
p.I406T	TCGA-A8-A09R	BRCA	TCGA	PESTS	DEG_SPOP_SBC_1	0.1389
p.I406T	DO3542	BRCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.1389
p.T400M	TCGA-AA-A01Z	COAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.3056
p.T400M	TCGA-AX-A0J1	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	0.3056
p.T400M	DO8392	COAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.T400M	DO233064	GACA	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.T400M	DO41199	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	0.3056
p.S390N	TCGA-AX-A2HD	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	0.1944
p.S390N	DO42608	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	0.1944
p.S390N	ACH-002041	Thyroid Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.1944
p.E387K	TCGA-QB-AA9O	SKCM	TCGA	PESTS	DEG_SPOP_SBC_1	0.1111
p.E387K	DO51267	SKCM	ICGC	PESTS	DEG_SPOP_SBC_1	0.1111
p.D407E	SIDM01577	Plasma Cell Myeloma	GDSC	PESTS	DEG_SPOP_SBC_1	0.1111
p.D407E	ACH-000889	Myeloma	CCLE	PESTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons