DegronMD

Uniprot ID: P53804

Source protein: E3 ubiquitin-protein ligase TTC3

Source gene: TTC3

Class: DEG_SPOP_SBC_1

Location: 1449:1453

E3 ligase: SPOP

DEGRON score: 0.7321

ASA_SCORE: 86.56

COIL: 0.8458

CONS_SCORE: 0.3861

DSS_SCORE: 0.3999

HELIX: 0.1118

FCONS_SCORE: 0.951

RIG_SCORE: 0.7525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1460Y	TCGA-CF-A47Y	BLCA	TCGA	PESTS	DEG_SPOP_SBC_1	0.1389
p.H1460Y	DO44050	BLCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.1389
p.N1457S	TCGA-CG-5721	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.2222
p.N1457S	DO38192	STAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.2222
p.Q1462R	TCGA-DD-A1EE	LIHC	TCGA	PESTS	DEG_SPOP_SBC_1	0.0833
p.Q1462R	TCGA-G3-A25S	LIHC	TCGA	PESTS	DEG_SPOP_SBC_1	0.0833
p.Q1462R	DO23018	LIHC	ICGC	PESTS	DEG_SPOP_SBC_1	0.0833
p.Q1462R	DO22857	LIHC	ICGC	PESTS	DEG_SPOP_SBC_1	0.0833
p.Q1462H	TCGA-DK-AA74	BLCA	TCGA	PESTS	DEG_SPOP_SBC_1	0.0833
p.Q1462H	DO219011	BLCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.0833
p.G1439R	TCGA-FW-A3R5	SKCM	TCGA	PESTS	DEG_SPOP_SBC_1	0.0556
p.G1439R	DO37406	SKCM	ICGC	PESTS	DEG_SPOP_SBC_1	0.0556
p.S1451C	DO23516	LIRI	ICGC	PESTS	DEG_SPOP_SBC_1	0.7541
p.H1460Q	DO230929	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.1389
p.H1460Q	DO224572	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.1389
p.N1442K	DO229253	THCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.1389
p.V1461M	SIDM00995	Other Solid Cancers	GDSC	PESTS	DEG_SPOP_SBC_1	0.1111
p.V1461M	ACH-001328	Skin Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.1111
p.V1461M	A431	skin	COSMIC	PESTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons