DegronMD - Q9Y4A8(NFE2L3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V194A	TCGA-AA-3947	COAD	TCGA	EPTAQVPDA	DEG_COP1_1	176:184	Mutation rewiring degron network	0.0556
p.V194A	DO8192	COAD	ICGC	EPTAQVPDA	DEG_COP1_1	176:184	Mutation rewiring degron network	0.0556
p.S509C	TCGA-GV-A6ZA	BLCA	TCGA	PESTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7541
p.S509C	DO49776	BLCA	ICGC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7541
p.G168E	DO234261	ESAD	ICGC	EPTAQVPDA	DEG_COP1_1	176:184	Mutation rewiring degron network	0.1111
p.Q503H	DO234317	ESAD	ICGC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.W516C	DO229006	LICA	ICGC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.G518R	DO23462	LINC	ICGC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.E169G	DO218858	SKCA	ICGC	EPTAQVPDA	DEG_COP1_1	176:184	Mutation rewiring degron network	0.1389
p.H498L	SIDM00135	Breast Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0833
p.H498L	ACH-000148	Breast Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0833
p.H498L	Hs-578-T	breast	COSMIC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0833
p.P504R	SIDM01162	Kidney Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.25
p.P504R	ACH-001398	Kidney Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.25
p.P504R	SW156	kidney	COSMIC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.25
p.G138E	ACH-000090	Prostate Cancer	CCLE	AASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.2778
p.G129V	ACH-000878	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.25
p.V181A	ACH-000940	Endometrial/Uterine Cancer	CCLE	EPTAQVPDA	DEG_COP1_1	176:184	Mutation altering degron motif	0.6936
p.G126R	ACH-000974	Endometrial/Uterine Cancer	CCLE	AASST	DEG_SPOP_SBC_1	132:136	Mutation rewiring degron network	0.1667
p.A132T	ACH-001513	Cervical Cancer	CCLE	AASST	DEG_SPOP_SBC_1	132:136	Mutation altering degron motif	0.7139
p.S511F	MKN7	stomach	COSMIC	PESTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7982

Kaplan plot for NFE2L3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFE2L3

UniProt ID: Q9Y4A8

Entrez ID: 9603

Protein name: Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFE2L3 in