DegronMD

Uniprot ID: Q9Y4A8

Source protein: Nuclear factor erythroid 2-related factor 3

Source gene: NFE2L3

Class: DEG_COP1_1

Location: 176:184

E3 ligase: COP1

DEGRON score: 0.9722

ASA_SCORE: 81.3111

COIL: 0.8821

CONS_SCORE: 0.46

DSS_SCORE: 0.7605

HELIX: 0.0778

FCONS_SCORE: 1.0429

RIG_SCORE: 0.6493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V194A	TCGA-AA-3947	COAD	TCGA	EPTAQVPDA	DEG_COP1_1	0.0556
p.V194A	DO8192	COAD	ICGC	EPTAQVPDA	DEG_COP1_1	0.0556
p.G168E	DO234261	ESAD	ICGC	EPTAQVPDA	DEG_COP1_1	0.1111
p.E169G	DO218858	SKCA	ICGC	EPTAQVPDA	DEG_COP1_1	0.1389
p.V181A	ACH-000940	Endometrial/Uterine Cancer	CCLE	EPTAQVPDA	DEG_COP1_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_COP1_1	176:184	EPTAQVPDA	COP1	0.9722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons