DegronMD

Uniprot ID: Q9Y4A8

Source protein: Nuclear factor erythroid 2-related factor 3

Source gene: NFE2L3

Class: DEG_SPOP_SBC_1

Location: 507:511

E3 ligase: SPOP

DEGRON score: 0.8238

ASA_SCORE: 91.76

COIL: 0.9354

CONS_SCORE: 0.2859

DSS_SCORE: 0.6039

HELIX: 0.0482

FCONS_SCORE: 0.563

RIG_SCORE: 0.6254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S509C	TCGA-GV-A6ZA	BLCA	TCGA	PESTS	DEG_SPOP_SBC_1	0.7541
p.S509C	DO49776	BLCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.7541
p.Q503H	DO234317	ESAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.2222
p.W516C	DO229006	LICA	ICGC	PESTS	DEG_SPOP_SBC_1	0.1944
p.G518R	DO23462	LINC	ICGC	PESTS	DEG_SPOP_SBC_1	0.1389
p.H498L	SIDM00135	Breast Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.0833
p.H498L	ACH-000148	Breast Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.0833
p.H498L	Hs-578-T	breast	COSMIC	PESTS	DEG_SPOP_SBC_1	0.0833
p.P504R	SIDM01162	Kidney Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.25
p.P504R	ACH-001398	Kidney Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.25
p.P504R	SW156	kidney	COSMIC	PESTS	DEG_SPOP_SBC_1	0.25
p.S511F	MKN7	stomach	COSMIC	PESTS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons