DegronMD - O00221(NFKBIE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T172A	TCGA-D8-A1XK	BRCA	TCGA	PESTS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7139
p.T172A	DO4749	BRCA	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7139
p.A251T	TCGA-GS-A9TZ	DLBC	TCGA	PRLPLPHVG	DEG_APCC_DBOX_1	234:242	Mutation rewiring degron network	0.0833
p.A251T	DO219918	DLBC	ICGC	PRLPLPHVG	DEG_APCC_DBOX_1	234:242	Mutation rewiring degron network	0.0833
p.E149K	TCGA-JW-A5VL	CESC	TCGA	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation rewiring degron network	0.1389
p.E149K	DO49976	CESC	ICGC	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation rewiring degron network	0.1389
p.Y155H	DO5745	BRCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation blocking phosphorylation signal	0.75
p.P147L	DO222534	BTCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation rewiring degron network	0.0833
p.P175L	DO229003	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO229005	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO223154	ESCA	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO229346	LAML	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO229480	LAML	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO230934	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO230990	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO231102	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P175L	DO231114	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.L162M	DO229221	THCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation rewiring degron network	0.3056
p.L162M	DO229221	THCA	ICGC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.G158V	DO229221	THCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation altering degron motif	0.7532
p.S161C	SIDM00479	Esophageal Carcinoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation altering degron motif	0.8652
p.S161C	ACH-000679	Esophageal Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation altering degron motif	0.8652
p.S171P	ACH-000541	Myeloma	CCLE	PESTS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.6752
p.S171P	ACH-000672	Lung Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.6752
p.R163C	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	156:161	Mutation rewiring degron network	0.2778
p.R163C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1667
p.R172Q	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PESTS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7329
p.L232M	SNU-1040	large intestine	COSMIC	PRLPLPHVG	DEG_APCC_DBOX_1	234:242	Mutation rewiring degron network	0.2778

Kaplan plot for NFKBIE in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFKBIE

UniProt ID: O00221

Entrez ID: 4794

Protein name: NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFKBIE in