DegronMD

Uniprot ID: O00221

Source protein: NF-kappa-B inhibitor epsilon

Source gene: NFKBIE

Class: DEG_SCF_TRCP1_1

Location: 156:161

E3 ligase: BTRC

DEGRON score: 0.9794

ASA_SCORE: 46.65

COIL: 0.644

CONS_SCORE: 0.5208

DSS_SCORE: 0.6881

HELIX: 0.2785

FCONS_SCORE: 1.1495

RIG_SCORE: 0.6717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E149K	TCGA-JW-A5VL	CESC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.E149K	DO49976	CESC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.Y155H	DO5745	BRCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.75
p.P147L	DO222534	BTCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.0833
p.L162M	DO229221	THCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.G158V	DO229221	THCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.7532
p.S161C	SIDM00479	Esophageal Carcinoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	0.8652
p.S161C	ACH-000679	Esophageal Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.8652
p.R163C	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons