DegronMD

Uniprot ID: Q49AJ0

Source protein: Protein FAM135B

Source gene: FAM135B

Class: DEG_SCF_TRCP1_1

Location: 685:690

E3 ligase: BTRC

DEGRON score: 0.8994

ASA_SCORE: 84.6333

COIL: 0.8812

CONS_SCORE: 0.3567

DSS_SCORE: 0.3974

HELIX: 0.0693

FCONS_SCORE: 1.1009

RIG_SCORE: 0.625

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S684C	TCGA-21-1077	LUSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.S684C	DO26725	LUSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.V695I	TCGA-29-1770	OV	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.V695I	TCGA-A6-5661	COAD	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.V695I	DO8634	COAD	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.V695I	DO31664	OV	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.I683V	TCGA-AX-A1CE	UCEC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.2778
p.I683V	DO42280	UCEC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.2778
p.R678K	TCGA-AX-A2HC	UCEC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.R678K	TCGA-EB-A41B	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.R678K	TCGA-F5-6814	READ	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.R678K	DO36556	READ	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.R678K	DO37611	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.R678K	DO41572	UCEC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.R678G	TCGA-BK-A6W3	UCEC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.R678G	DO50076	UCEC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.A700V	TCGA-C9-A47Z	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.0556
p.A700V	DO44423	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.0556
p.V695F	TCGA-CN-5355	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.V695F	DO14638	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.W697L	TCGA-CV-A45W	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.W697L	DO52060	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.E689Q	TCGA-ER-A19E	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.5633
p.E689Q	DO47542	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.5633
p.S693C	TCGA-F4-6703	COAD	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.25
p.S693C	DO9908	COAD	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.25
p.S684P	TCGA-F7-A624	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.S684P	DO44440	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.S680L	TCGA-FW-A3R5	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.S680L	DO37406	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.S680L	SIDM00336	Melanoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.S680L	ACH-000881	Skin Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.S680L	MEL-JUSO	skin	COSMIC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.D685N	TCGA-WE-A8ZN	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	0.6932
p.D685N	DO51285	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.6932
p.E691D	DO48236	ESCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.A696T	DO233208	GACA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1667
p.D685V	DO45169	LIRI	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.7785
p.S690N	DO222536	MELA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.7069
p.A696G	SIDM00299	Other Sarcomas	GDSC	DSGIES	DEG_SCF_TRCP1_1	0.1667
p.A696G	ACH-002271	Sarcoma	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.1667
p.A696G	MFH-ino	soft_tissue	COSMIC	DSGIES	DEG_SCF_TRCP1_1	0.1667
p.E691K	SIDM00537	Colorectal Carcinoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.E691K	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.E691K	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.3056
p.E691K	GP5d	large_intestine	COSMIC	DSGIES	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SCF_TRCP1_1	156:161	DSGIES	BTRC	0.9794	More...
Q2M1P5	Kinesin-like protein KIF7	DEG_SCF_TRCP1_1	461:466	DSGIES	BTRC	0.7936	More...
Q49AJ0	Protein FAM135B	DEG_SCF_TRCP1_1	685:690	DSGIES	BTRC	0.8994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGIES

Degron related mutations and impact score

Drug responses associated with FAM135B mutations

All proteins holding degron of DSGIES