DegronMD - Q2M1P5(KIF7)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S455T	DO4695	BRCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1667
p.S466R	DO229019	LICA	ICGC	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation altering degron motif	0.7427
p.I464V	SIDM00594	Acute Myeloid Leukemia	GDSC	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation altering degron motif	0.5965
p.I464V	HEL	haematopoietic and lymphoid tissue	COSMIC	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation altering degron motif	0.5965
p.S456F	SIDM00002	Neuroblastoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1944
p.S456F	SIDM00394	Cervical Carcinoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1944
p.S456F	ACH-001650	Cervical Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1944
p.S456F	SISO	cervix	COSMIC	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1944
p.G459R	ACH-001001	Bone Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.2778
p.A473V	ACH-001369	Ovarian Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1389
p.S456C	ACH-001973	Metastasis	CCLE	DSGIES	DEG_SCF_TRCP1_1	461:466	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons