DegronMD

Uniprot ID: Q2M1P5

Source protein: Kinesin-like protein KIF7

Source gene: KIF7

Class: DEG_SCF_TRCP1_1

Location: 461:466

E3 ligase: BTRC

DEGRON score: 0.7936

ASA_SCORE: 85.0167

COIL: 0.5162

CONS_SCORE: 0.338

DSS_SCORE: 0.6165

HELIX: 0.4647

FCONS_SCORE: 1.0021

RIG_SCORE: 0.6016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S455T	DO4695	BRCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.1667
p.S466R	DO229019	LICA	ICGC	DSGIES	DEG_SCF_TRCP1_1	0.7427
p.I464V	SIDM00594	Acute Myeloid Leukemia	GDSC	DSGIES	DEG_SCF_TRCP1_1	0.5965
p.I464V	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIES	DEG_SCF_TRCP1_1	0.5965
p.S456F	SIDM00002	Neuroblastoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.S456F	SIDM00394	Cervical Carcinoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.S456F	ACH-001650	Cervical Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.S456F	SISO	cervix	COSMIC	DSGIES	DEG_SCF_TRCP1_1	0.1944
p.G459R	ACH-001001	Bone Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.2778
p.A473V	ACH-001369	Ovarian Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.1389
p.S456C	ACH-001973	Metastasis	CCLE	DSGIES	DEG_SCF_TRCP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons