DegronMD - Q49AJ0(FAM135B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D653H	TCGA-17-Z055	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1667
p.L648M	TCGA-18-5592	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	TCGA-60-2722	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	TCGA-99-8032	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	DO23765	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	DO26432	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	DO26798	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	SIDM00596	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	ACH-000941	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	ACH-000954	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	ACH-001517	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.L648M	HEC-1	endometrium	COSMIC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.S684C	TCGA-21-1077	LUSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.S684C	DO26725	LUSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.V695I	TCGA-29-1770	OV	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.V695I	TCGA-A6-5661	COAD	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.V695I	DO8634	COAD	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.V695I	DO31664	OV	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.S593R	TCGA-43-A56U	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.6316
p.S593R	DO49083	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.6316
p.I605F	TCGA-49-AARQ	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0833
p.I605F	DO51189	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0833
p.D588N	TCGA-55-7994	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.5821
p.D588N	DO45311	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.5821
p.D588N	SIDM00032	Bladder Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.5821
p.Q602K	TCGA-56-1622	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.Q602K	TCGA-BH-A0B6	BRCA	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.Q602K	DO2641	BRCA	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.Q602K	DO26461	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.H601Q	TCGA-56-1622	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.H601Q	DO26461	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.Y585N	TCGA-58-A46M	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.25
p.Y585N	DO45485	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.25
p.S606Y	TCGA-63-A5MT	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S606Y	DO219163	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.P637T	TCGA-78-7542	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1667
p.P637T	DO24760	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1667
p.S606F	TCGA-86-8359	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S606F	TCGA-AX-A2HC	UCEC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S606F	TCGA-EB-A44O	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S606F	DO25817	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S606F	DO47272	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S606F	DO41572	UCEC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.G598V	TCGA-97-8179	LUAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G598V	DO25709	LUAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.P643A	TCGA-A2-A0SU	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.6392
p.P643A	DO6104	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.6392
p.T636I	TCGA-AA-A01R	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.T636I	DO7934	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.I683V	TCGA-AX-A1CE	UCEC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.2778
p.I683V	DO42280	UCEC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.2778
p.R678K	TCGA-AX-A2HC	UCEC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.R678K	TCGA-EB-A41B	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.R678K	TCGA-F5-6814	READ	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.R678K	DO36556	READ	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.R678K	DO37611	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.R678K	DO41572	UCEC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.G586E	TCGA-BF-AAP1	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586E	DO219464	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586E	SIDM01175	Other Sarcomas	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586E	SIDM00290	Gastric Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586E	ACH-000847	Gastric Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586E	ACH-002309	Sarcoma	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586E	SW684	soft tissue	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586E	HGC-27	stomach	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.R678G	TCGA-BK-A6W3	UCEC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.R678G	DO50076	UCEC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.S645R	TCGA-BR-4366	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	TCGA-BR-A4PD	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	TCGA-CG-5728	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	TCGA-EO-A3B0	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	TCGA-FW-A3I3	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO50435	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO234381	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO234313	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO37503	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO38419	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO38619	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO47831	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.S645R	DO219773	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7427
p.A700V	TCGA-C9-A47Z	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.0556
p.A700V	DO44423	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.0556
p.V695F	TCGA-CN-5355	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.V695F	DO14638	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.S645N	TCGA-CQ-6220	HNSC	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7069
p.S645N	DO15902	HNSC	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7069
p.S581C	TCGA-CV-6961	HNSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.S581C	DO14566	HNSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.W697L	TCGA-CV-A45W	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.W697L	DO52060	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1389
p.R589K	TCGA-CV-A468	HNSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7237
p.R589K	TCGA-EE-A2GJ	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7237
p.R589K	DO52070	HNSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7237
p.R589K	DO37746	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7237
p.A604V	TCGA-D6-6516	HNSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.A604V	DO15623	HNSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.K594N	TCGA-D7-A4YU	STAD	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.5806
p.K594N	DO47761	STAD	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.5806
p.L592I	TCGA-DD-A73F	LIHC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7174
p.L592I	DO48587	LIHC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7174
p.D653Y	TCGA-E6-A1LX	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1667
p.D653Y	DO41020	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1667
p.G586R	TCGA-EE-A20C	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586R	DO222775	MELA	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G586R	DO47665	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G599E	TCGA-EE-A2GJ	SKCM	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.25
p.G599E	DO37746	SKCM	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.25
p.S646F	TCGA-EE-A2MD	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7982
p.S646F	DO222434	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7982
p.S646F	DO37851	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7982
p.S657F	TCGA-EE-A2MR	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0556
p.S657F	TCGA-RP-A694	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0556
p.S657F	TCGA-W3-A825	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0556
p.S657F	DO222578	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0556
p.S657F	DO37819	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0556
p.S657F	DO51272	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0556
p.S657F	DO51269	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.0556
p.E689Q	TCGA-ER-A19E	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation altering degron motif	0.5633
p.E689Q	DO47542	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation altering degron motif	0.5633
p.S693C	TCGA-F4-6703	COAD	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.25
p.S693C	DO9908	COAD	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.25
p.S684P	TCGA-F7-A624	HNSC	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.S684P	DO44440	HNSC	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.D583N	TCGA-FA-A7Q1	DLBC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.D583N	DO219890	DLBC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.E650V	TCGA-FI-A2D5	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.E650V	DO41331	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.S680L	TCGA-FW-A3R5	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.S680L	DO37406	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.S680L	SIDM00336	Melanoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.S680L	ACH-000881	Skin Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.S680L	MEL-JUSO	skin	COSMIC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1944
p.D583Y	TCGA-G5-6235	READ	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.D583Y	DO36612	READ	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.P640T	TCGA-L9-A743	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.P640T	DO49874	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.A604T	TCGA-NC-A5HQ	LUSC	TCGA	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.A604T	DO219201	LUSC	ICGC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.C641S	TCGA-R6-A8W5	ESCA	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.D685N	TCGA-WE-A8ZN	SKCM	TCGA	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation altering degron motif	0.6932
p.D685N	DO51285	SKCM	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation altering degron motif	0.6932
p.I654N	TCGA-WE-AAA0	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.I654N	DO51294	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1389
p.K634N	TCGA-ZR-A9CJ	ESCA	TCGA	PLSST	DEG_SPOP_SBC_1	643:647	Mutation substituting flanking lysine	0.1944
p.K634N	DO50393	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation substituting flanking lysine	0.1944
p.S638C	DO1075	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1944
p.E639D	DO234385	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.E691D	DO48236	ESCA	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.A696T	DO233208	GACA	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1667
p.L644I	DO229031	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.6063
p.D685V	DO45169	LIRI	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation altering degron motif	0.7785
p.L644P	DO231022	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.6471
p.S690N	DO222536	MELA	ICGC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation altering degron motif	0.7069
p.E639K	DO229446	SKCA	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.D642N	DO218863	SKCA	ICGC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.3056
p.C641R	SIDM01301	Esophageal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.S578N	SIDM00773	Non-Cancerous	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S578N	SIDM00210	Ovarian Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S578N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S578N	SIDM00774	Breast Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S646Y	SIDM00652	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.712
p.S646Y	ACH-000780	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.712
p.S646Y	NCI-H1105	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.712
p.P640L	SIDM00417	Plasma Cell Myeloma	GDSC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.P640L	ACH-000626	Myeloma	CCLE	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.P640L	U-266	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.R589M	SIDM01120	Other Solid Cancers	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8632
p.R589M	ACH-002174	Lung Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8632
p.R589M	NCI-H720	lung	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8632
p.A604S	SIDM01045	Endometrial Carcinoma	GDSC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.A604S	ACH-000978	Endometrial/Uterine Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.A604S	EN	endometrium	COSMIC	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.A696G	SIDM00299	Other Sarcomas	GDSC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1667
p.A696G	ACH-002271	Sarcoma	CCLE	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1667
p.A696G	MFH-ino	soft tissue	COSMIC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.1667
p.S645I	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7341
p.S645I	ACH-000873	Esophageal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7341
p.S645I	KYSE-270	oesophagus	COSMIC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.7341
p.E691K	SIDM00537	Colorectal Carcinoma	GDSC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.E691K	ACH-000982	Colon/Colorectal Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.E691K	ACH-001345	Colon/Colorectal Cancer	CCLE	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.E691K	GP5d	large intestine	COSMIC	DSGIES	DEG_SCF_TRCP1_1	685:690	Mutation rewiring degron network	0.3056
p.R649M	SIDM01750	Melanoma	GDSC	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.R649M	ACH-000801	Skin Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.L587F	ACH-001407	Bladder Cancer	CCLE	DRTGLSKVV	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM135B

UniProt ID: Q49AJ0

Entrez ID: 51059

Protein name: Protein FAM135B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM135B in