DegronMD

Uniprot ID: Q49AJ0

Source protein: Protein FAM135B

Source gene: FAM135B

Class: DEG_SPOP_SBC_1

Location: 643:647

E3 ligase: SPOP

DEGRON score: 0.9487

ASA_SCORE: 77.9

COIL: 0.8868

CONS_SCORE: 0.2943

DSS_SCORE: 0.5436

HELIX: 0.085

FCONS_SCORE: 1.0601

RIG_SCORE: 0.6822

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D653H	TCGA-17-Z055	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.1667
p.L648M	TCGA-18-5592	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	TCGA-60-2722	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	TCGA-99-8032	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	DO23765	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	DO26432	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	DO26798	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	SIDM00596	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	ACH-000941	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	ACH-000954	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	ACH-001517	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.3056
p.L648M	HEC-1	endometrium	COSMIC	PLSST	DEG_SPOP_SBC_1	0.3056
p.P637T	TCGA-78-7542	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.1667
p.P637T	DO24760	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.1667
p.P643A	TCGA-A2-A0SU	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	0.6392
p.P643A	DO6104	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.6392
p.T636I	TCGA-AA-A01R	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.1389
p.T636I	DO7934	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.1389
p.S645R	TCGA-BR-4366	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	TCGA-BR-A4PD	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	TCGA-CG-5728	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	TCGA-EO-A3B0	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	TCGA-FW-A3I3	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO50435	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO234381	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO234313	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO37503	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO38419	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO38619	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO47831	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645R	DO219773	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	0.7427
p.S645N	TCGA-CQ-6220	HNSC	TCGA	PLSST	DEG_SPOP_SBC_1	0.7069
p.S645N	DO15902	HNSC	ICGC	PLSST	DEG_SPOP_SBC_1	0.7069
p.D653Y	TCGA-E6-A1LX	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	0.1667
p.D653Y	DO41020	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	0.1667
p.S646F	TCGA-EE-A2MD	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.7982
p.S646F	DO222434	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	0.7982
p.S646F	DO37851	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.7982
p.S657F	TCGA-EE-A2MR	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.0556
p.S657F	TCGA-RP-A694	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.0556
p.S657F	TCGA-W3-A825	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.0556
p.S657F	DO222578	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	0.0556
p.S657F	DO37819	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.0556
p.S657F	DO51272	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.0556
p.S657F	DO51269	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.0556
p.E650V	TCGA-FI-A2D5	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	0.25
p.E650V	DO41331	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	0.25
p.P640T	TCGA-L9-A743	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.25
p.P640T	DO49874	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.25
p.C641S	TCGA-R6-A8W5	ESCA	TCGA	PLSST	DEG_SPOP_SBC_1	0.2778
p.I654N	TCGA-WE-AAA0	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.1389
p.I654N	DO51294	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.1389
p.K634N	TCGA-ZR-A9CJ	ESCA	TCGA	PLSST	DEG_SPOP_SBC_1	0.1944
p.K634N	DO50393	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.1944
p.S638C	DO1075	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.1944
p.E639D	DO234385	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.2222
p.L644I	DO229031	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	0.6063
p.L644P	DO231022	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	0.6471
p.E639K	DO229446	SKCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.2222
p.D642N	DO218863	SKCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.3056
p.C641R	SIDM01301	Esophageal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.2778
p.S646Y	SIDM00652	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.712
p.S646Y	ACH-000780	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.712
p.S646Y	NCI-H1105	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	0.712
p.P640L	SIDM00417	Plasma Cell Myeloma	GDSC	PLSST	DEG_SPOP_SBC_1	0.25
p.P640L	ACH-000626	Myeloma	CCLE	PLSST	DEG_SPOP_SBC_1	0.25
p.P640L	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.25
p.S645I	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.7341
p.S645I	ACH-000873	Esophageal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.7341
p.S645I	KYSE-270	oesophagus	COSMIC	PLSST	DEG_SPOP_SBC_1	0.7341
p.R649M	SIDM01750	Melanoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.2778
p.R649M	ACH-000801	Skin Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	659:663	PLSST	SPOP	0.9969	More...
O43525	Potassium voltage-gated channel subfamily KQT member 3	DEG_SPOP_SBC_1	852:856	PLSST	SPOP	0.9413	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	371:375	PLSST	SPOP	0.9973	More...
P58107	Epiplakin	DEG_SPOP_SBC_1	797:801	PLSST	SPOP	0.7149	More...
Q13873	Bone morphogenetic protein receptor type-2	DEG_SPOP_SBC_1	698:702	PLSST	SPOP	0.9891	More...
Q13950	Runt-related transcription factor 2	DEG_SPOP_SBC_1	320:324	PLSST	SPOP	0.9988	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	891:895	PLSST	SPOP	0.9403	More...
Q49AJ0	Protein FAM135B	DEG_SPOP_SBC_1	643:647	PLSST	SPOP	0.9487	More...
Q5M775	Cytospin-B	DEG_SPOP_SBC_1	342:346	PLSST	SPOP	0.9835	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_SPOP_SBC_1	1123:1127	PLSST	SPOP	0.9913	More...
Q69YN4	Protein virilizer homolog	DEG_SPOP_SBC_1	1757:1761	PLSST	SPOP	0.9993	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	336:340	PLSST	SPOP	0.984	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	1665:1669	PLSST	SPOP	0.9861	More...
Q8IW45	ATP-dependent	DEG_SPOP_SBC_1	63:67	PLSST	SPOP	0.9107	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1684:1688	PLSST	SPOP	0.9408	More...
Q92546	RAB6A-GEF complex partner protein 2	DEG_SPOP_SBC_1	306:310	PLSST	SPOP	0.6123	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	393:397	PLSST	SPOP	0.9714	More...
Q96PX1	E3 ubiquitin ligase RNF157	DEG_SPOP_SBC_1	499:503	PLSST	SPOP	0.976	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	71:75	PLSST	SPOP	0.9941	More...
Q9NR46	Endophilin-B2	DEG_SPOP_SBC_1	295:299	PLSST	SPOP	0.6401	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	DEG_SPOP_SBC_1	1908:1912	PLSST	SPOP	0.9775	More...
Q9Y2W1	Thyroid hormone receptor-associated protein 3	DEG_SPOP_SBC_1	276:280	PLSST	SPOP	0.9859	More...
Q5VVH5	Interleukin-1 receptor-associated kinase 1-binding protein 1	DEG_SPOP_SBC_1	40:44	PLSST	SPOP	0.9797	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	452:456	PLSST	SPOP	0.8986	More...
Q9Y5F7	Protocadherin gamma-C4	DEG_SPOP_SBC_1	544:548	PLSST	SPOP	0.8845	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSST

Degron related mutations and impact score

Drug responses associated with FAM135B mutations

All proteins holding degron of PLSST