DegronMD - Q9P0X4(CACNA1I)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1914I	TCGA-06-0152	GBM	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.2778
p.E1904K	TCGA-06-5416	GBM	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.2222
p.R1898S	TCGA-17-Z055	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.0556
p.R1898L	TCGA-44-7667	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.0556
p.D1917H	TCGA-49-AARE	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1944
p.L1922V	TCGA-66-2755	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.0556
p.A2S	TCGA-A5-A0G2	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.A2S	DO41235	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.G1900R	TCGA-A5-A0G2	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1111
p.N244K	TCGA-A5-A1OF	UCEC	TCGA	PPYY	ITCH	254:257	Mutation rewiring degron network	0.0556
p.N244K	DO42568	UCEC	ICGC	PPYY	ITCH	254:257	Mutation rewiring degron network	0.0556
p.E1919D	TCGA-A5-A2K5	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1389
p.E1919D	TCGA-AG-A002	READ	TCGA	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1389
p.S565W	TCGA-A6-3810	COAD	TCGA	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.1667
p.F245L	TCGA-DM-A1HB	COAD	TCGA	PPYY	ITCH	254:257	Mutation rewiring degron network	0.0833
p.A17T	TCGA-EB-A5UL	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1667
p.A17T	DO47601	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1667
p.R1899G	DO224802	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.0833
p.E577Q	DO8224	COAD	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.6744
p.P1911Q	DO227802	COCA	ICGC	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation altering degron motif	0.7035
p.A5T	DO222774	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2778
p.P259L	DO233069	GACA	ICGC	PPYY	ITCH	254:257	Mutation rewiring degron network	0.2778
p.P259L	DO227804	PBCA	ICGC	PPYY	ITCH	254:257	Mutation rewiring degron network	0.2778
p.D581H	DO229346	LAML	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.2222
p.E578D	DO229041	LICA	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.3056
p.A1918T	DO52330	LIHC	ICGC	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1667
p.D1917N	DO47368	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1944
p.D581N	DO47368	SKCM	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.2222
p.P1916T	DO47607	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.2222
p.G571E	DO219481	SKCM	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.7199
p.G565R	DO229259	THCA	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.1667
p.D262G	DO229208	THCA	ICGC	PPYY	ITCH	254:257	Mutation rewiring degron network	0.1944
p.D262E	SIDM02045	Colorectal Carcinoma	GDSC	PPYY	ITCH	254:257	Mutation rewiring degron network	0.1944
p.P7L	SIDM01265	Plasma Cell Myeloma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00773	Non-Cancerous	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM01090	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00529	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00844	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00793	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00930	Osteosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00954	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00774	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM00257	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM01173	Rhabdomyosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM01318	Hepatocellular Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.P7L	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7582
p.A583T	SIDM00401	Melanoma	GDSC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.1667
p.P15S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.P15S	ACH-001362	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.P15S	NCI-H1770	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.T1912M	SIDM00861	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation altering degron motif	0.7423
p.A12T	SIDM01617	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.A12T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.R562W	ACH-000894	Lung Cancer	CCLE	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.0833
p.S579Y	ACH-000927	Breast Cancer	CCLE	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.2778
p.A2T	ACH-001127	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.E18K	ACH-001484	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1389
p.E18K	ACH-001485	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1389
p.S1915L	ACH-001536	Bile Duct Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.25
p.G565A	H2591	pleura	COSMIC	DSGQEGS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.1667

Kaplan plot for CACNA1I in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1I

UniProt ID: Q9P0X4

Entrez ID: 8911

Protein name: Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNA1I in