DegronMD

Uniprot ID: Q9P0X4

Source protein: Voltage-dependent T-type calcium channel subunit alpha-1I

Source gene: CACNA1I

Class: DEG_SCF_TRCP1_1

Location: 571:577

E3 ligase: BTRC

DEGRON score: 0.9942

ASA_SCORE: 68.5286

COIL: 0.769

CONS_SCORE: 0.3494

DSS_SCORE: 0.7877

HELIX: 0.1171

FCONS_SCORE: 1.179

RIG_SCORE: 0.4977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S565W	TCGA-A6-3810	COAD	TCGA	DSGQEGS	DEG_SCF_TRCP1_1	0.1667
p.E577Q	DO8224	COAD	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	0.6744
p.D581H	DO229346	LAML	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	0.2222
p.E578D	DO229041	LICA	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	0.3056
p.D581N	DO47368	SKCM	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	0.2222
p.G571E	DO219481	SKCM	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	0.7199
p.G565R	DO229259	THCA	ICGC	DSGQEGS	DEG_SCF_TRCP1_1	0.1667
p.A583T	SIDM00401	Melanoma	GDSC	DSGQEGS	DEG_SCF_TRCP1_1	0.1667
p.R562W	ACH-000894	Lung Cancer	CCLE	DSGQEGS	DEG_SCF_TRCP1_1	0.0833
p.S579Y	ACH-000927	Breast Cancer	CCLE	DSGQEGS	DEG_SCF_TRCP1_1	0.2778
p.G565A	H2591	pleura	COSMIC	DSGQEGS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	DEG_SCF_TRCP1_1	571:577	DSGQEGS	BTRC	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons