DegronMD

Uniprot ID: Q9P0X4

Source protein: Voltage-dependent T-type calcium channel subunit alpha-1I

Source gene: CACNA1I

Class: DEG_SPOP_SBC_1

Location: 7:11

E3 ligase: SPOP

DEGRON score: 0.8266

ASA_SCORE: 79.58

COIL: 0.8944

CONS_SCORE: 0.2344

DSS_SCORE: 0.7987

HELIX: 0.1004

FCONS_SCORE: 1.0389

RIG_SCORE: 0.5023

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P7L	SIDM01265	Plasma Cell Myeloma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00773	Non-Cancerous	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM01090	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00529	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00844	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00793	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00930	Osteosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00954	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00774	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM00257	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM01173	Rhabdomyosarcoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM01318	Hepatocellular Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P7L	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.A12T	SIDM01617	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.3056
p.A12T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	0.3056
p.A5T	DO222774	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.2778
p.P15S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.2222
p.P15S	ACH-001362	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	0.2222
p.P15S	NCI-H1770	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	0.2222
p.A2S	TCGA-A5-A0G2	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	0.1944
p.A2S	DO41235	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	0.1944
p.A2T	ACH-001127	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	0.1944

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Drug responses associated with CACNA1I mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2J0	7SK snRNA methylphosphate capping enzyme	DEG_SPOP_SBC_1	355:359	PPSSS	SPOP	0.9939	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1285:1289	PPSSS	SPOP	0.8542	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	1509:1513	PPSSS	SPOP	0.9954	More...
Q8NC96	Adaptin ear-binding coat-associated protein 1	DEG_SPOP_SBC_1	199:203	PPSSS	SPOP	0.9883	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	444:448	PPSSS	SPOP	0.8502	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1642:1646	PPSSS	SPOP	0.917	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	82:86	PPSSS	SPOP	0.9981	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	252:256	PPSSS	SPOP	0.9757	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	482:486	PPSSS	SPOP	0.8891	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	827:831	PPSSS	SPOP	0.9934	More...
Q8IXM2	Chromatin complexes subunit BAP18	DEG_SPOP_SBC_1	117:121	PPSSS	SPOP	0.9693	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	165:169	PPSSS	SPOP	0.8162	More...
Q5T3F8	CSC1-like protein 2	DEG_SPOP_SBC_1	796:800	PPSSS	SPOP	0.9523	More...
O14976	Cyclin-G-associated kinase	DEG_SPOP_SBC_1	781:785	PPSSS	SPOP	0.9989	More...
P51813	Cytoplasmic tyrosine-protein kinase BMX	DEG_SPOP_SBC_1	206:210	PPSSS	SPOP	0.9857	More...
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	DEG_SPOP_SBC_1	568:572	PPSSS	SPOP	0.987	More...
Q96EV8	Dysbindin	DEG_SPOP_SBC_1	295:299	PPSSS	SPOP	0.9933	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	810:814	PPSSS	SPOP	0.9752	More...
O95714	E3 ubiquitin-protein ligase HERC2	DEG_SPOP_SBC_1	2632:2636	PPSSS	SPOP	0.9299	More...
P50402	Emerin	DEG_SPOP_SBC_1	50:54	PPSSS	SPOP	0.9872	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	799:803	PPSSS	SPOP	0.6205	More...
P04150	Glucocorticoid receptor	DEG_SPOP_SBC_1	405:409	PPSSS	SPOP	0.8508	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	297:301	PPSSS	SPOP	0.9284	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	393:397	PPSSS	SPOP	0.9958	More...
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SPOP_SBC_1	1759:1763	PPSSS	SPOP	0.964	More...

Showing 1 to 25 of 85 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSSS

Degron related mutations and impact score

Drug responses associated with CACNA1I mutations

All proteins holding degron of PPSSS