DegronMD - P51825(AFF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T447N	TCGA-13-2057	OV	TCGA	PPSSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.7055
p.K868R	TCGA-58-8387	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.3056
p.T298M	TCGA-60-2723	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.T298M	DO27152	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.R302W	TCGA-A5-A1OJ	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1944
p.R302W	TCGA-D1-A17T	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1944
p.R302W	DO42496	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1944
p.R302W	DO42817	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1944
p.A299T	TCGA-A5-A2K5	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2778
p.A299T	DO41379	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2778
p.E500K	TCGA-AC-A3YI	BRCA	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation altering degron motif	0.7022
p.E500K	TCGA-V5-AASV	ESCA	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation altering degron motif	0.7022
p.P465S	TCGA-AN-A0XN	BRCA	TCGA	AHSSS	DEG_SPOP_SBC_1	464:468	Mutation altering degron motif	0.6752
p.S474N	TCGA-AP-A1DK	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	464:468	Mutation rewiring degron network	0.1667
p.R30C	TCGA-AX-A0J1	UCEC	TCGA	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30C	TCGA-AX-A0J1	UCEC	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.R30C	TCGA-KN-8425	KICH	TCGA	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30C	TCGA-KN-8425	KICH	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.R30C	DO220474	KICH	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30C	DO220474	KICH	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.R30C	DO41199	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30C	DO41199	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.E493K	TCGA-AX-A1C9	UCEC	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.2222
p.M304V	TCGA-AX-A2HC	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1389
p.M304V	DO41572	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1389
p.S867L	TCGA-B5-A11E	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.2778
p.S867L	TCGA-CR-6480	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.2778
p.S574Y	TCGA-BC-A10W	LIHC	TCGA	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1667
p.P458A	TCGA-CD-A4MG	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.0556
p.P458A	TCGA-CD-A4MG	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	464:468	Mutation rewiring degron network	0.1667
p.D441Y	TCGA-CN-A63U	HNSC	TCGA	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	436:443	Mutation altering degron motif	0.7325
p.S860F	TCGA-CR-6480	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.0833
p.S470L	TCGA-D3-A1QA	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	464:468	Mutation rewiring degron network	0.2778
p.P873S	TCGA-D6-6516	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	869:873	Mutation altering degron motif	0.6752
p.D489Y	TCGA-DV-5565	KIRC	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.1111
p.E506G	TCGA-DV-A4VX	KIRC	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.2778
p.P282S	TCGA-EB-A3Y7	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation substituting flanking lysine	0.25
p.P282S	DO23140	LINC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation substituting flanking lysine	0.25
p.P282S	DO45033	LINC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation substituting flanking lysine	0.25
p.P282S	DO37499	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation substituting flanking lysine	0.25
p.P452L	TCGA-EB-A85J	SKCM	TCGA	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	436:443	Mutation rewiring degron network	0.0833
p.P452L	TCGA-EB-A85J	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	444:448	Mutation rewiring degron network	0.2222
p.R30H	TCGA-EO-A22R	UCEC	TCGA	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30H	TCGA-EO-A22R	UCEC	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.R30H	DO42713	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30H	DO42713	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.R30H	SIDM00120	Prostate Carcinoma	GDSC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30H	SIDM00120	Prostate Carcinoma	GDSC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.R30H	DU-145	prostate	COSMIC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.R30H	DU-145	prostate	COSMIC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.T426M	TCGA-EY-A1G8	UCEC	TCGA	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	436:443	Mutation rewiring degron network	0.0556
p.P287S	TCGA-FR-A726	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2778
p.P287S	DO48665	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2778
p.D489G	TCGA-GI-A2C8	BRCA	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.1111
p.L505I	TCGA-GN-A26C	SKCM	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.3056
p.P514H	TCGA-IB-7651	PAAD	TCGA	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.0556
p.P46S	TCGA-IH-A3EA	SKCM	TCGA	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation substituting flanking lysine	0.3611
p.P46S	TCGA-IH-A3EA	SKCM	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation substituting flanking lysine	0.3611
p.P46S	DO37667	SKCM	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation substituting flanking lysine	0.3611
p.P46S	DO37667	SKCM	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation substituting flanking lysine	0.3611
p.S285F	TCGA-IH-A3EA	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2222
p.S285F	TCGA-WE-AAA0	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2222
p.S285F	DO37667	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2222
p.S285F	DO51294	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2222
p.P42S	TCGA-KU-A6H7	HNSC	TCGA	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6752
p.P42S	TCGA-KU-A6H7	HNSC	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation altering degron motif	0.6752
p.P42S	DO52089	HNSC	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6752
p.P42S	DO52089	HNSC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation altering degron motif	0.6752
p.S290C	TCGA-NJ-A4YI	LUAD	TCGA	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7541
p.S290C	DO218942	LUAD	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7541
p.H472R	TCGA-VR-A8EW	ESCA	TCGA	AHSSS	DEG_SPOP_SBC_1	464:468	Mutation rewiring degron network	0.2222
p.P51S	TCGA-YG-AA3O	SKCM	TCGA	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.P51S	TCGA-YG-AA3O	SKCM	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1111
p.P51S	DO51299	SKCM	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.P51S	DO51299	SKCM	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1111
p.E445K	TCGA-ZF-A9RL	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	444:448	Mutation altering degron motif	0.7022
p.E325K	DO219044	BLCA	ICGC	DYR	CBL_MET	316:318	Mutation blocking phosphorylation signal	0.5833
p.V33D	DO486	BLCA	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.V33D	DO486	BLCA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.2222
p.S53F	DO44192	BRCA	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0556
p.S53F	DO44192	BRCA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.0556
p.K308R	DO49975	CESC	ICGC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.1111
p.A316T	DO223732	CESC	ICGC	DYR	CBL_MET	316:318	Mutation altering degron motif	0.7139
p.S565L	DO6254	CESC	ICGC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7667
p.R466S	DO44096	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	464:468	Mutation altering degron motif	0.7427
p.K469T	DO8264	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	464:468	Mutation rewiring degron network	0.3056
p.A316V	DO234183	ESAD	ICGC	DYR	CBL_MET	316:318	Mutation altering degron motif	0.6936
p.P319A	DO234335	ESAD	ICGC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.3056
p.V283L	DO234287	ESAD	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1667
p.K284N	DO222717	ESCA	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1944
p.P505L	DO233634	GACA	ICGC	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.3056
p.D573E	DO233747	GACA	ICGC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.D573E	DO45299	LIRI	ICGC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.G49E	DO11854	GBM	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation substituting flanking lysine	0.2778
p.G49E	DO11854	GBM	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation substituting flanking lysine	0.2778
p.L321V	DO49070	HNSC	ICGC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.25
p.S53C	DO14310	HNSC	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0556
p.S53C	DO14310	HNSC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.0556
p.P504S	DO15623	HNSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation altering degron motif	0.6752
p.S491F	DO14296	HNSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation rewiring degron network	0.1667
p.S498L	DO14296	HNSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation altering degron motif	0.7667
p.S498L	DO41644	UCEC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation altering degron motif	0.7667
p.P429L	DO22237	LGG	ICGC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	436:443	Mutation rewiring degron network	0.1389
p.E50D	DO228976	LICA	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1389
p.E50D	DO228976	LICA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.D323Y	DO228986	LICA	ICGC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.1944
p.S34I	DO229026	LICA	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.2222
p.S34I	DO229026	LICA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.25
p.Q279H	DO23430	LINC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.0556
p.E557K	DO229177	LMS	ICGC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.R440S	DO23690	LUAD	ICGC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	436:443	Mutation altering degron motif	0.7427
p.R440S	DO37146	READ	ICGC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	436:443	Mutation altering degron motif	0.7427
p.K499R	DO45445	LUSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation altering degron motif	0.7237
p.S304Y	DO232761	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1389
p.Q327H	DO232224	PBCA	ICGC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.0833
p.A310T	DO232224	PBCA	ICGC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.1667
p.L503P	DO219881	SKCA	ICGC	PLETPAPE	DEG_SCF_FBW7_2	497:504	Mutation altering degron motif	0.7582
p.G558W	DO48009	STAD	ICGC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1667
p.K307E	DO42023	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation blocking phosphorylation signal	0.5
p.K307E	DO42023	UCEC	ICGC	DYR	CBL_MET	316:318	Mutation blocking phosphorylation signal	0.5278
p.V301A	DO41752	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2222
p.S35Y	DO41758	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.25
p.S35Y	DO41758	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.2778
p.A320V	DO42608	UCEC	ICGC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.2778
p.S30Y	DO42568	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1111
p.S30Y	DO42568	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	37:43	Mutation rewiring degron network	0.1389
p.G572R	DO43827	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2222
p.S570Y	DO42713	UCEC	ICGC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2778
p.A292T	DO41331	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7139
p.S428F	SIDM02035	Colorectal Carcinoma	GDSC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	436:443	Mutation rewiring degron network	0.1111
p.S290N	SIDM00422	Hodgkin's Lymphoma	GDSC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7069
p.S290N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7069
p.P571A	SIDM01197	Colorectal Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.P571A	SIDM00235	Kidney Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.P571A	SIDM00576	Acute Myeloid Leukemia	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.P571A	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.P571A	SIDM00302	Other Solid Cancers	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.P571A	SIDM01575	Plasma Cell Myeloma	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.P571A	SIDM01450	Gastric Carcinoma	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.K296N	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.6918
p.K296N	LK-2	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.6918
p.D305Y	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1111
p.D305Y	VMRC-LCD	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1111
p.D308Y	SIDM00153	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.1111
p.S560R	SIDM01749	Osteosarcoma	GDSC	PKSSS	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.3333
p.Q327E	SIDM01554	Mesothelioma	GDSC	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.0833
p.M293V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7208
p.Q320E	ACH-000331	Lung Cancer	CCLE	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.2778
p.K289N	ACH-000769	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.5806
p.K289N	LK-2	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation altering degron motif	0.5806
p.P314T	ACH-000831	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	316:318	Mutation rewiring degron network	0.2778
p.M286V	ACH-000942	Leukemia	CCLE	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.25
p.D301Y	ACH-000964	Leukemia	CCLE	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2222
p.S283N	ACH-001203	Lymphoma	CCLE	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1667
p.S283N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1667
p.D298Y	ACH-001233	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.D298Y	VMRC-LCD	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.Q287L	ACH-001570	Skin Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.2778
p.V870M	ACH-001613	Leukemia	CCLE	PVSSS	DEG_SPOP_SBC_1	869:873	Mutation altering degron motif	0.6097

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFF1

UniProt ID: P51825

Entrez ID: 4299

Protein name: AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AFF1 in