DegronMD

Uniprot ID: P51825

Source protein: AF4/FMR2 family member 1

Source gene: AFF1

Class: DEG_SCF_FBW7_2

Location: 497:504

E3 ligase: FBXW7

DEGRON score: 0.889

ASA_SCORE: 105.275

COIL: 0.9596

CONS_SCORE: 0.4598

DSS_SCORE: 0.901

HELIX: 0.0191

FCONS_SCORE: 0.8261

RIG_SCORE: 0.5545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E500K	TCGA-AC-A3YI	BRCA	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.7022
p.E500K	TCGA-V5-AASV	ESCA	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.7022
p.E493K	TCGA-AX-A1C9	UCEC	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.2222
p.D489Y	TCGA-DV-5565	KIRC	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.1111
p.E506G	TCGA-DV-A4VX	KIRC	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.2778
p.D489G	TCGA-GI-A2C8	BRCA	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.1111
p.L505I	TCGA-GN-A26C	SKCM	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.3056
p.P514H	TCGA-IB-7651	PAAD	TCGA	PLETPAPE	DEG_SCF_FBW7_2	0.0556
p.P505L	DO233634	GACA	ICGC	PLETPAPE	DEG_SCF_FBW7_2	0.3056
p.P504S	DO15623	HNSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	0.6752
p.S491F	DO14296	HNSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	0.1667
p.S498L	DO14296	HNSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	0.7667
p.S498L	DO41644	UCEC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	0.7667
p.K499R	DO45445	LUSC	ICGC	PLETPAPE	DEG_SCF_FBW7_2	0.7237
p.L503P	DO219881	SKCA	ICGC	PLETPAPE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51825	AF4/FMR2 family member 1	DEG_SCF_FBW7_2	497:504	PLETPAPE	FBXW7	0.889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons