DegronMD

Uniprot ID: P51825

Source protein: AF4/FMR2 family member 1

Source gene: AFF1

Class: LIG_APCC_ABBA_1

Location: 38:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9812

ASA_SCORE: 51.7

COIL: 0.8943

CONS_SCORE: 0.4688

DSS_SCORE: 0.5124

HELIX: 0.0338

FCONS_SCORE: 1.0465

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R30C	TCGA-AX-A0J1	UCEC	TCGA	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.R30C	TCGA-KN-8425	KICH	TCGA	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.R30C	DO220474	KICH	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.R30C	DO41199	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.R30H	TCGA-EO-A22R	UCEC	TCGA	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.R30H	DO42713	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.R30H	SIDM00120	Prostate Carcinoma	GDSC	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.R30H	DU-145	prostate	COSMIC	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.P46S	TCGA-IH-A3EA	SKCM	TCGA	IPLFGE	LIG_APCC_ABBA_1	0.3611
p.P46S	DO37667	SKCM	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.3611
p.P42S	TCGA-KU-A6H7	HNSC	TCGA	IPLFGE	LIG_APCC_ABBA_1	0.6752
p.P42S	DO52089	HNSC	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.6752
p.P51S	TCGA-YG-AA3O	SKCM	TCGA	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.P51S	DO51299	SKCM	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.1111
p.V33D	DO486	BLCA	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.1944
p.S53F	DO44192	BRCA	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.0556
p.G49E	DO11854	GBM	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.2778
p.S53C	DO14310	HNSC	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.0556
p.E50D	DO228976	LICA	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.1389
p.S34I	DO229026	LICA	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.2222
p.S35Y	DO41758	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.25
p.S30Y	DO42568	UCEC	ICGC	IPLFGE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51825	AF4/FMR2 family member 1	LIG_APCC_ABBA_1	38:43	IPLFGE	APC,CDC20,FZR1	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons