DegronMD

Uniprot ID: P51825

Source protein: AF4/FMR2 family member 1

Source gene: AFF1

Class: LIG_APCC_ABBAyCdc20_2

Location: 37:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9511

ASA_SCORE: 64.7857

COIL: 0.8814

CONS_SCORE: 0.4558

DSS_SCORE: 0.516

HELIX: 0.0463

FCONS_SCORE: 1.0183

RIG_SCORE: 0.725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R30C	TCGA-AX-A0J1	UCEC	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R30C	TCGA-KN-8425	KICH	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R30C	DO220474	KICH	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R30C	DO41199	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R30H	TCGA-EO-A22R	UCEC	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R30H	DO42713	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R30H	SIDM00120	Prostate Carcinoma	GDSC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R30H	DU-145	prostate	COSMIC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P46S	TCGA-IH-A3EA	SKCM	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.3611
p.P46S	DO37667	SKCM	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.3611
p.P42S	TCGA-KU-A6H7	HNSC	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.6752
p.P42S	DO52089	HNSC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.6752
p.P51S	TCGA-YG-AA3O	SKCM	TCGA	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P51S	DO51299	SKCM	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V33D	DO486	BLCA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S53F	DO44192	BRCA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G49E	DO11854	GBM	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S53C	DO14310	HNSC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E50D	DO228976	LICA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S34I	DO229026	LICA	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.S35Y	DO41758	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S30Y	DO42568	UCEC	ICGC	KIPLFGE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51825	AF4/FMR2 family member 1	LIG_APCC_ABBAyCdc20_2	37:43	KIPLFGE	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons