DegronMD

Uniprot ID: P51825

Source protein: AF4/FMR2 family member 1

Source gene: AFF1

Class: DEG_SCF_SKP2-CKS1_1

Location: 436:443

E3 ligase: SKP2,CSK1

DEGRON score: 0.9158

ASA_SCORE: 116.825

COIL: 0.918

CONS_SCORE: 0.4502

DSS_SCORE: 0.9254

HELIX: 0.0701

FCONS_SCORE: 0.8451

RIG_SCORE: 0.5045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D441Y	TCGA-CN-A63U	HNSC	TCGA	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	0.7325
p.P452L	TCGA-EB-A85J	SKCM	TCGA	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	0.0833
p.T426M	TCGA-EY-A1G8	UCEC	TCGA	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P429L	DO22237	LGG	ICGC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R440S	DO23690	LUAD	ICGC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	0.7427
p.R440S	DO37146	READ	ICGC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S428F	SIDM02035	Colorectal Carcinoma	GDSC	DSEQTPEK	DEG_SCF_SKP2-CKS1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51825	AF4/FMR2 family member 1	DEG_SCF_SKP2-CKS1_1	436:443	DSEQTPEK	SKP2,CSK1	0.9158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons