DegronMD

Uniprot ID: P51825

Source protein: AF4/FMR2 family member 1

Source gene: AFF1

Class: DEG_SIAH_1

Location: 289:297

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9757

ASA_SCORE: 107.1

COIL: 0.9443

CONS_SCORE: 0.4112

DSS_SCORE: 0.7362

HELIX: 0.022

FCONS_SCORE: 0.8567

RIG_SCORE: 0.665

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T298M	TCGA-60-2723	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.3056
p.T298M	DO27152	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.3056
p.R302W	TCGA-A5-A1OJ	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.1944
p.R302W	TCGA-D1-A17T	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.1944
p.R302W	DO42496	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.R302W	DO42817	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.A299T	TCGA-A5-A2K5	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2778
p.A299T	DO41379	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.M304V	TCGA-AX-A2HC	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.1389
p.M304V	DO41572	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1389
p.P282S	TCGA-EB-A3Y7	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	0.25
p.P282S	DO23140	LINC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.25
p.P282S	DO45033	LINC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.25
p.P282S	DO37499	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	0.25
p.P287S	TCGA-FR-A726	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2778
p.P287S	DO48665	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.S285F	TCGA-IH-A3EA	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2222
p.S285F	TCGA-WE-AAA0	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2222
p.S285F	DO37667	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2222
p.S285F	DO51294	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2222
p.S290C	TCGA-NJ-A4YI	LUAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.7541
p.S290C	DO218942	LUAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7541
p.V283L	DO234287	ESAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1667
p.K284N	DO222717	ESCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.Q279H	DO23430	LINC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.0556
p.S304Y	DO232761	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1389
p.K307E	DO42023	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.5
p.V301A	DO41752	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2222
p.A292T	DO41331	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7139
p.S290N	SIDM00422	Hodgkin's Lymphoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.7069
p.S290N	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.7069
p.K296N	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.6918
p.K296N	LK-2	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.6918
p.D305Y	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.1111
p.D305Y	VMRC-LCD	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.1111
p.M293V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	KPTAYVRPM	DEG_SIAH_1	0.7208
p.K289N	ACH-000769	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.5806
p.K289N	LK-2	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.5806
p.M286V	ACH-000942	Leukemia	CCLE	KPTAYVRPM	DEG_SIAH_1	0.25
p.D301Y	ACH-000964	Leukemia	CCLE	KPTAYVRPM	DEG_SIAH_1	0.2222
p.S283N	ACH-001203	Lymphoma	CCLE	KPTAYVRPM	DEG_SIAH_1	0.1667
p.S283N	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.1667
p.D298Y	ACH-001233	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.3056
p.D298Y	VMRC-LCD	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.3056
p.Q287L	ACH-001570	Skin Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51816	AF4/FMR2 family member 2	DEG_SIAH_1	284:292	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.9759	More...
P51825	AF4/FMR2 family member 1	DEG_SIAH_1	289:297	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.9757	More...
P51826	AF4/FMR2 family member 3	DEG_SIAH_1	230:238	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.96	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SIAH_1	252:260	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPTAYVRPM

Degron related mutations and impact score

Drug responses associated with AFF1 mutations

All proteins holding degron of KPTAYVRPM