DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: DEG_SIAH_1

Location: 284:292

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9759

ASA_SCORE: 100.7444

COIL: 0.9016

CONS_SCORE: 0.4528

DSS_SCORE: 0.6227

HELIX: 0.0292

FCONS_SCORE: 1.2423

RIG_SCORE: 0.7358

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T278A	TCGA-56-7822	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.1667
p.R290I	TCGA-63-A5MM	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.6991
p.M280T	TCGA-BR-8487	STAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2222
p.G294D	TCGA-D1-A1NY	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2778
p.L274I	TCGA-DC-5869	READ	TCGA	KPTAYVRPM	DEG_SIAH_1	0.0556
p.Q283H	TCGA-DF-A2KV	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.3056
p.D293N	TCGA-EE-A2MR	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	0.3056
p.I301M	TCGA-ZG-A9KY	PRAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.0833
p.L301V	DO2401	BRCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.0833
p.L301P	DO233882	GACA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.0833
p.K280N	DO228380	LICA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2222
p.T282I	DO50970	LICA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.T274A	DO26638	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.0556
p.R286I	DO219153	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.8102
p.G290A	DO33512	PACA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.754
p.I297M	DO219412	PRAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.D289N	DO37819	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	0.6932
p.M276T	DO47867	STAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1111
p.Q279H	DO219771	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.G290D	DO42512	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7198
p.P299T	SIDM00690	Head and Neck Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.1389
p.P299T	ACH-002251	Head and Neck Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.1389
p.P299T	JHU-029	upper_aerodigestive_tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.1389
p.P285S	SIDM00889	Cervical Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.6752
p.P285S	ACH-001333	Cervical Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.6752
p.P285S	C-33-A	cervix	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.6752
p.D282E	Ca9-22	upper_aerodigestive_tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.D282E	NCI-H1568	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.P295T	JHU-029	upper_aerodigestive_tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.25
p.T292I	CW-2	large_intestine	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.7078
p.P281S	C-33-A	cervix	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.25
p.S301N	CCK-81	large_intestine	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51816	AF4/FMR2 family member 2	DEG_SIAH_1	284:292	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.9759	More...
P51825	AF4/FMR2 family member 1	DEG_SIAH_1	289:297	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.9757	More...
P51826	AF4/FMR2 family member 3	DEG_SIAH_1	230:238	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.96	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SIAH_1	252:260	KPTAYVRPM	SIAH1,SIAH2,SIAH3	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPTAYVRPM

Degron related mutations and impact score

Drug responses associated with AFF2 mutations

All proteins holding degron of KPTAYVRPM