DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: DEG_SIAH_1

Location: 284:292

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9759

ASA_SCORE: 100.7444

COIL: 0.9016

CONS_SCORE: 0.4528

DSS_SCORE: 0.6227

HELIX: 0.0292

FCONS_SCORE: 1.2423

RIG_SCORE: 0.7358

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R286I	DO219153	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.8102
p.G290A	DO33512	PACA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.754
p.G290D	DO42512	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7198
p.T292I	CW-2	large_intestine	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.7078
p.R290I	TCGA-63-A5MM	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.6991
p.D289N	DO37819	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	0.6932
p.P285S	SIDM00889	Cervical Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.6752
p.P285S	ACH-001333	Cervical Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.6752
p.P285S	C-33-A	cervix	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.6752
p.Q283H	TCGA-DF-A2KV	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.3056
p.D293N	TCGA-EE-A2MR	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	0.3056
p.G294D	TCGA-D1-A1NY	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2778
p.T282I	DO50970	LICA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.D282E	Ca9-22	upper_aerodigestive_tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.D282E	NCI-H1568	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.P295T	JHU-029	upper_aerodigestive_tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.25
p.P281S	C-33-A	cervix	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.25
p.M280T	TCGA-BR-8487	STAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2222
p.K280N	DO228380	LICA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2222
p.I297M	DO219412	PRAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.Q279H	DO219771	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.T278A	TCGA-56-7822	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.1667
p.P299T	SIDM00690	Head and Neck Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.1389
p.P299T	ACH-002251	Head and Neck Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.1389
p.P299T	JHU-029	upper_aerodigestive_tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons