DegronMD

Uniprot ID: Q9UHB7

Source protein: AF4/FMR2 family member 4

Source gene: AFF4

Class: DEG_SIAH_1

Location: 252:260

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9885

ASA_SCORE: 103.6667

COIL: 0.9517

CONS_SCORE: 0.5497

DSS_SCORE: 0.6622

HELIX: 0.0216

FCONS_SCORE: 0.9891

RIG_SCORE: 0.7078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T254I	TCGA-43-6771	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.5966
p.T254I	DO26443	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.5966
p.E264K	TCGA-75-6207	LUAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2222
p.E264K	DO26190	LUAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2222
p.R258W	TCGA-AR-A0TZ	BRCA	TCGA	KPTAYVRPM	DEG_SIAH_1	0.7523
p.R258W	DO2287	BRCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7523
p.R258W	DO232761	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7523
p.R258W	DO232593	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7523
p.G262R	TCGA-CV-7413	HNSC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2778
p.G262R	DO15567	HNSC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.G262R	SIDM02072	Colorectal Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.2778
p.M249V	TCGA-F4-6463	COAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.25
p.M249V	DO7958	COAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons