DegronMD - Q9UHB7(AFF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P115H	TCGA-18-3407	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	114:118	Mutation altering degron motif	0.6583
p.P115H	DO26454	LUSC	ICGC	APSTS	DEG_SPOP_SBC_1	114:118	Mutation altering degron motif	0.6583
p.T254I	TCGA-43-6771	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation altering degron motif	0.5966
p.T254I	DO26443	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation altering degron motif	0.5966
p.E264K	TCGA-75-6207	LUAD	TCGA	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.2222
p.E264K	DO26190	LUAD	ICGC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.2222
p.G112V	TCGA-77-A5G6	LUSC	TCGA	APSTS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.2778
p.G112V	DO50097	LUSC	ICGC	APSTS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.2778
p.S885N	TCGA-AA-3855	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	882:886	Mutation altering degron motif	0.7069
p.S885N	DO10742	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation altering degron motif	0.7069
p.R258W	TCGA-AR-A0TZ	BRCA	TCGA	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7523
p.R258W	DO2287	BRCA	ICGC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7523
p.R258W	DO232761	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7523
p.R258W	DO232593	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7523
p.A138T	TCGA-CG-4306	STAD	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.A138T	TCGA-D1-A163	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.A138T	DO38567	STAD	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.A138T	DO41008	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7139
p.G262R	TCGA-CV-7413	HNSC	TCGA	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.2778
p.G262R	DO15567	HNSC	ICGC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.2778
p.G262R	SIDM02072	Colorectal Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.2778
p.S142T	TCGA-DD-AAD2	LIHC	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.6005
p.S142T	DO52219	LIHC	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.6005
p.P346S	TCGA-EE-A2MC	SKCM	TCGA	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1667
p.P346S	TCGA-ER-A19W	SKCM	TCGA	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1667
p.P346S	DO229502	SKCA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1667
p.P346S	DO37559	SKCM	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1667
p.P346S	DO50300	SKCM	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1667
p.Q128H	TCGA-EE-A2MQ	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.0556
p.Q128H	TCGA-EE-A2MQ	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.Q128H	DO37810	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.0556
p.Q128H	DO37810	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.P330H	TCGA-ER-A19Q	SKCM	TCGA	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.2222
p.P330H	DO47497	SKCM	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.2222
p.K344T	TCGA-EY-A1G8	UCEC	TCGA	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation blocking ubiquitination signal	0.6667
p.K344T	DO43578	UCEC	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation blocking ubiquitination signal	0.6667
p.M249V	TCGA-F4-6463	COAD	TCGA	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.25
p.M249V	DO7958	COAD	ICGC	KPTAYVRPM	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.25
p.S106I	TCGA-R5-A7ZI	STAD	TCGA	APSTS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.1111
p.S106I	DO222342	STAD	ICGC	APSTS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.1111
p.P894L	DO233114	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1111
p.H891N	DO228971	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1944
p.N888K	DO228986	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.2778
p.T349N	DO229029	LICA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.0833
p.T893N	DO229035	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1389
p.P337T	DO229045	LICA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation altering degron motif	0.7031
p.A333D	DO229049	LICA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.3056
p.S875F	DO220881	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation blocking phosphorylation signal	0.5833
p.T893S	DO222349	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1389
p.G143D	SIDM01278	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.A138V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.5825
p.A138V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.5825
p.A138V	ACH-000995	Leukemia	CCLE	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.5825
p.A138V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.5825
p.P891L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1944
p.P891L	ACH-000995	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1944
p.P891L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.1944
p.S326L	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1111
p.S326L	ACH-000893	Lung Cancer	CCLE	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1111
p.S326L	NCI-H1651	lung	COSMIC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1111
p.P890L	SIDM00341	Squamous Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.2222
p.P890L	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.2222
p.P890L	LOU-NH91	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.2222
p.P890L	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.2222
p.T136P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.7222
p.F347V	ACH-000132	Ovarian Cancer	CCLE	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1389
p.F347V	JHOS-2	ovary	COSMIC	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1389
p.K881N	ACH-000791	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.3056
p.D152N	ACH-000961	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.T895S	ACH-001539	Lymphoma	CCLE	APSSS	DEG_SPOP_SBC_1	882:886	Mutation rewiring degron network	0.0833
p.P346L	ACH-001551	Skin Cancer	CCLE	IHTPCKT	DEG_SCF_FBW7_1	334:340	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFF4

UniProt ID: Q9UHB7

Entrez ID: 27125

Protein name: AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AFF4 in