DegronMD

Uniprot ID: Q9UHB7

Source protein: AF4/FMR2 family member 4

Source gene: AFF4

Class: DEG_SCF_FBW7_1

Location: 334:340

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 103.9143

COIL: 0.9553

CONS_SCORE: 0.6195

DSS_SCORE: 0.5375

HELIX: 0.014

FCONS_SCORE: 1.1551

RIG_SCORE: 0.7247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P346S	TCGA-EE-A2MC	SKCM	TCGA	IHTPCKT	DEG_SCF_FBW7_1	0.1667
p.P346S	TCGA-ER-A19W	SKCM	TCGA	IHTPCKT	DEG_SCF_FBW7_1	0.1667
p.P346S	DO229502	SKCA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.1667
p.P346S	DO37559	SKCM	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.1667
p.P346S	DO50300	SKCM	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.1667
p.P330H	TCGA-ER-A19Q	SKCM	TCGA	IHTPCKT	DEG_SCF_FBW7_1	0.2222
p.P330H	DO47497	SKCM	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.2222
p.K344T	TCGA-EY-A1G8	UCEC	TCGA	IHTPCKT	DEG_SCF_FBW7_1	0.6667
p.K344T	DO43578	UCEC	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.6667
p.T349N	DO229029	LICA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.0833
p.P337T	DO229045	LICA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.7031
p.A333D	DO229049	LICA	ICGC	IHTPCKT	DEG_SCF_FBW7_1	0.3056
p.S326L	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	IHTPCKT	DEG_SCF_FBW7_1	0.1111
p.S326L	ACH-000893	Lung Cancer	CCLE	IHTPCKT	DEG_SCF_FBW7_1	0.1111
p.S326L	NCI-H1651	lung	COSMIC	IHTPCKT	DEG_SCF_FBW7_1	0.1111
p.F347V	ACH-000132	Ovarian Cancer	CCLE	IHTPCKT	DEG_SCF_FBW7_1	0.1389
p.F347V	JHOS-2	ovary	COSMIC	IHTPCKT	DEG_SCF_FBW7_1	0.1389
p.P346L	ACH-001551	Skin Cancer	CCLE	IHTPCKT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHB7	AF4/FMR2 family member 4	DEG_SCF_FBW7_1	334:340	IHTPCKT	FBXW7	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons