DegronMD - P51816(AFF2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H366N	TCGA-05-4398	LUAD	TCGA	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.H366N	DO25847	LUAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.S374F	TCGA-09-2053	OV	TCGA	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7982
p.S374F	DO31060	OV	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7982
p.P389S	TCGA-38-4629	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1389
p.P389S	DO23771	LUAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1389
p.P132T	TCGA-38-4632	LUAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.P398L	TCGA-44-6779	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.7582
p.K56N	TCGA-55-A492	LUAD	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation substituting flanking lysine	0.3611
p.K56N	DO23708	LUAD	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation substituting flanking lysine	0.3611
p.T278A	TCGA-56-7822	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.1667
p.R290I	TCGA-63-A5MM	LUSC	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.6991
p.E519D	TCGA-69-7979	LUAD	TCGA	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.5647
p.E519D	DO23874	LUAD	ICGC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.5647
p.T505S	TCGA-75-6214	LUAD	TCGA	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.0556
p.T505S	DO24830	LUAD	ICGC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.0556
p.Q127H	TCGA-86-A456	LUAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.647
p.D128Y	TCGA-86-A456	LUAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7325
p.Q391H	TCGA-A6-3809	COAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1944
p.Q391H	TCGA-B5-A3FA	UCEC	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1944
p.Q391H	DO8722	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1944
p.Q391H	DO52402	UCEC	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1944
p.T130A	TCGA-AA-A00N	COAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2778
p.K119N	TCGA-AG-3892	READ	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation substituting flanking lysine	0.3333
p.K119N	TCGA-AP-A0LM	UCEC	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation substituting flanking lysine	0.3333
p.K119N	TCGA-EY-A1G8	UCEC	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation substituting flanking lysine	0.3333
p.V57I	TCGA-AP-A059	UCEC	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.2222
p.D42N	TCGA-AP-A1DV	UCEC	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42N	TCGA-D3-A51T	SKCM	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42N	TCGA-EA-A6QX	CESC	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42N	DO48997	CESC	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42N	DO47389	SKCM	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42N	DO43186	UCEC	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42N	SIDM01588	Endometrial Carcinoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42N	ACH-000993	Endometrial/Uterine Cancer	CCLE	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.S45Y	TCGA-AX-A05Z	UCEC	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.25
p.S45Y	DO40884	UCEC	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.25
p.P513H	TCGA-B0-5097	KIRC	TCGA	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.2778
p.P513H	DO19370	KIRC	ICGC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.2778
p.E59K	TCGA-BH-A18U	BRCA	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.E59K	TCGA-FD-A3SS	BLCA	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.M280T	TCGA-BR-8487	STAD	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.2222
p.E40K	TCGA-C5-A1BI	CESC	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1111
p.E40K	DO44305	CESC	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1111
p.D407N	TCGA-C5-A8XK	CESC	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1667
p.G294D	TCGA-D1-A1NY	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.2778
p.L274I	TCGA-DC-5869	READ	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.0556
p.P371L	TCGA-DD-AAE0	LIHC	TCGA	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7582
p.P371L	DO52253	LIHC	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7582
p.Q283H	TCGA-DF-A2KV	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.3056
p.D42Y	TCGA-E9-A1N5	BRCA	TCGA	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42Y	DO6195	BRCA	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D293N	TCGA-EE-A2MR	SKCM	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.3056
p.S381Y	TCGA-FY-A3BL	THCA	TCGA	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.S381Y	DO40190	THCA	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.M364L	TCGA-G4-6295	COAD	TCGA	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1944
p.M364L	DO9362	COAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1944
p.P116S	TCGA-GN-A266	SKCM	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1389
p.R514H	TCGA-HT-7693	LGG	TCGA	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.3056
p.R514H	DO22191	LGG	ICGC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.3056
p.R362Q	TCGA-JY-A93C	ESCA	TCGA	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.P398S	TCGA-KL-8338	KICH	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.6752
p.P408T	TCGA-N6-A4VD	UCS	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1389
p.E392D	TCGA-O1-A52J	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.2222
p.P137S	TCGA-VQ-A8P2	STAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.0833
p.S387F	TCGA-YD-A89C	SKCM	TCGA	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.0833
p.S387F	DO219501	SKCM	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.0833
p.R362W	TCGA-YU-A90P	TGCT	TCGA	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.I301M	TCGA-ZG-A9KY	PRAD	TCGA	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.0833
p.G60C	DO225012	BRCA	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.P369R	DO225215	BRCA	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7512
p.P369R	DO227836	BRCA	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7512
p.L397V	DO228290	BRCA	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.6765
p.L301V	DO2401	BRCA	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.0833
p.N58S	DO222907	BTCA	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1944
p.D374N	DO49904	CESC	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.6932
p.S136Y	DO6308	CESC	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.S136Y	DO43041	UCEC	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.E398D	DO51732	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.6758
p.T126A	DO9876	COAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7139
p.K401N	DO8336	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.6918
p.P128A	DO222462	ESCA	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7503
p.D49N	DO228648	GACA	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation altering degron motif	0.5821
p.D49N	DO230535	LUSC	ICGC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation altering degron motif	0.5821
p.D374V	DO228648	GACA	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7785
p.L301P	DO233882	GACA	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.0833
p.L403V	DO233848	GACA	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.2778
p.L403V	DO38507	STAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.2778
p.D396G	DO12220	GBM	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.7198
p.P365S	DO220346	KICH	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.K280N	DO228380	LICA	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.2222
p.T282I	DO50970	LICA	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.2778
p.E398V	DO52318	LIHC	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.7693
p.E359D	DO218948	LUAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0556
p.P128T	DO23858	LUAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7031
p.P365L	DO23563	LUAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.D124Y	DO24890	LUAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7325
p.D124Y	DO232472	PBCA	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7325
p.Q123H	DO24890	LUAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7582
p.P399H	DO51193	LUAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.7694
p.P399H	LS-411N	large intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.7694
p.T274A	DO26638	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.0556
p.R286I	DO219153	LUSC	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.8102
p.P120L	DO220906	MELA	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.25
p.G366E	DO222843	MELA	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.A130T	DO33032	PACA	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2778
p.S360L	DO32887	PACA	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.Q529H	DO32893	PACA	ICGC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.1111
p.G290A	DO33512	PACA	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.754
p.I297M	DO219412	PRAD	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.1944
p.K115N	DO36394	READ	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.K115N	DO43306	UCEC	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.K115N	DO43578	UCEC	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.D289N	DO37819	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.6932
p.P133S	DO51761	STAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1944
p.M383I	DO47867	STAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0833
p.M276T	DO47867	STAD	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.1111
p.Q279H	DO219771	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.1944
p.G290D	DO42512	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.7198
p.T404I	DO42673	UCEC	ICGC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation blocking ubiquitination signal	0.6944
p.D41E	SIDM00845	Burkitt's Lymphoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.D41E	SIDM01519	Head and Neck Carcinoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.D41E	ACH-000786	Lymphoma	CCLE	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.D41E	ACH-000992	Head and Neck Cancer	CCLE	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.D41E	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.D41E	Daudi	haematopoietic and lymphoid tissue	COSMIC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1389
p.S374Y	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.S374Y	SIDM01199	Hepatocellular Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.S374Y	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.S374Y	SIDM00240	Cervical Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.S374Y	SLVL	haematopoietic and lymphoid tissue	COSMIC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.S374Y	OMC-1	cervix	COSMIC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.S374Y	KYSE-180	oesophagus	COSMIC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.S374Y	SNU-423	liver	COSMIC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.712
p.D42H	SIDM00120	Prostate Carcinoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42H	ACH-000979	Prostate Cancer	CCLE	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.D42H	DU-145	prostate	COSMIC	FDLFGE	LIG_APCC_ABBA_1	48:53	Mutation rewiring degron network	0.1667
p.T517N	SIDM00789	Colorectal Carcinoma	GDSC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.8166
p.T517N	ACH-000997	Colon/Colorectal Cancer	CCLE	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.8166
p.T517N	HCT-15	large intestine	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.8166
p.P299T	SIDM00690	Head and Neck Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.1389
p.P299T	ACH-002251	Head and Neck Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.1389
p.P299T	JHU-029	upper aerodigestive tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.1389
p.P132H	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.P132H	ACH-000853	Lung Cancer	CCLE	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.P132H	NCI-H661	lung	COSMIC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.P285S	SIDM00889	Cervical Carcinoma	GDSC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.6752
p.P285S	ACH-001333	Cervical Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.6752
p.P285S	C-33-A	cervix	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.6752
p.T401I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.8189
p.R362L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.R362L	NCI-H650	lung	COSMIC	PTPLTS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.G390R	SIDM00003	Melanoma	GDSC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1667
p.G390R	ACH-000884	Skin Cancer	CCLE	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1667
p.G390R	ACH-002159	Skin Cancer	CCLE	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1667
p.G390R	M14	skin	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1667
p.M136V	SIDM01608	Endometrial Carcinoma	GDSC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.M136V	ACH-000990	Endometrial/Uterine Cancer	CCLE	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.T525N	ACH-000872	Lung Cancer	CCLE	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.2222
p.G512D	SiHa	cervix	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.25
p.G512D	RERF-LC-MS	lung	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.25
p.S396G	KM12	large intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.6993
p.G514D	RERF-LC-MS	lung	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.3056
p.G514D	SiHa	cervix	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.3056
p.D282E	Ca9-22	upper aerodigestive tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.2778
p.D282E	NCI-H1568	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.2778
p.S398G	KM12	large intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation altering degron motif	0.6993
p.P403H	LS-411N	large intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.2778
p.P295T	JHU-029	upper aerodigestive tract	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.25
p.S392G	KM12	large intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.2222
p.G124S	MCC13	skin	COSMIC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.6993
p.S137L	KP-4	pancreas	COSMIC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.0833
p.R511H	TE-15	oesophagus	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.2222
p.P529T	IA-LM	lung	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.1111
p.T292I	CW-2	large intestine	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation altering degron motif	0.7078
p.M520I	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.7618
p.P128H	NCI-H661	lung	COSMIC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation altering degron motif	0.7694
p.P281S	C-33-A	cervix	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.25
p.E519K	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.591
p.S301N	CCK-81	large intestine	COSMIC	KPTAYVRPM	DEG_SIAH_1	284:292	Mutation rewiring degron network	0.0833
p.P524L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.25
p.P526L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation rewiring degron network	0.1944
p.S406N	GP5d	large intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.1944
p.P405H	LS-411N	large intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	396:401	Mutation rewiring degron network	0.2222
p.E130K	KM12	large intestine	COSMIC	IPPHQD	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2778
p.E521K	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.7022
p.M518I	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	515:521	Mutation altering degron motif	0.7618

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFF2

UniProt ID: P51816

Entrez ID: 2334

Protein name: AF4/FMR2 family member 2 (Fragile X E mental retardation syndrome protein) (Fragile X mental retardation 2 protein) (FMR2P) (Protein FMR-2) (Protein Ox19)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for AFF2 in