DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: DEG_SCF_FBW7_1

Location: 396:401

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 75.1833

COIL: 0.8945

CONS_SCORE: 0.4535

DSS_SCORE: 0.5895

HELIX: 0.0538

FCONS_SCORE: 1.1623

RIG_SCORE: 0.7234

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P389S	TCGA-38-4629	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1389
p.P389S	DO23771	LUAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.1389
p.P398L	TCGA-44-6779	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.7582
p.Q391H	TCGA-A6-3809	COAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.Q391H	TCGA-B5-A3FA	UCEC	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.Q391H	DO8722	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.Q391H	DO52402	UCEC	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.D407N	TCGA-C5-A8XK	CESC	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1667
p.P398S	TCGA-KL-8338	KICH	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.6752
p.P408T	TCGA-N6-A4VD	UCS	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1389
p.E392D	TCGA-O1-A52J	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.2222
p.S387F	TCGA-YD-A89C	SKCM	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.0833
p.S387F	DO219501	SKCM	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.0833
p.L397V	DO228290	BRCA	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6765
p.E398D	DO51732	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6758
p.K401N	DO8336	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6918
p.L403V	DO233848	GACA	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.2778
p.L403V	DO38507	STAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.2778
p.D396G	DO12220	GBM	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.7198
p.E398V	DO52318	LIHC	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.7693
p.P399H	DO51193	LUAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.7694
p.P399H	LS-411N	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.7694
p.T404I	DO42673	UCEC	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6944
p.T401I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	LTPGFT	DEG_SCF_FBW7_1	0.8189
p.G390R	SIDM00003	Melanoma	GDSC	LTPGFT	DEG_SCF_FBW7_1	0.1667
p.G390R	ACH-000884	Skin Cancer	CCLE	LTPGFT	DEG_SCF_FBW7_1	0.1667
p.G390R	ACH-002159	Skin Cancer	CCLE	LTPGFT	DEG_SCF_FBW7_1	0.1667
p.G390R	M14	skin	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.1667
p.S396G	KM12	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.6993
p.S398G	KM12	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.6993
p.P403H	LS-411N	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.2778
p.S392G	KM12	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.2222
p.S406N	GP5d	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.P405H	LS-411N	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPGFT

Degron related mutations and impact score

Drug responses associated with AFF2 mutations

All proteins holding degron of LTPGFT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51816	AF4/FMR2 family member 2	DEG_SCF_FBW7_1	396:401	LTPGFT	FBXW7	0.9957	More...