DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: DEG_SCF_FBW7_1

Location: 396:401

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 75.1833

COIL: 0.8945

CONS_SCORE: 0.4535

DSS_SCORE: 0.5895

HELIX: 0.0538

FCONS_SCORE: 1.1623

RIG_SCORE: 0.7234

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T401I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	LTPGFT	DEG_SCF_FBW7_1	0.8189
p.P399H	DO51193	LUAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.7694
p.P399H	LS-411N	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.7694
p.E398V	DO52318	LIHC	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.7693
p.P398L	TCGA-44-6779	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.7582
p.D396G	DO12220	GBM	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.7198
p.S396G	KM12	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.6993
p.S398G	KM12	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.6993
p.T404I	DO42673	UCEC	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6944
p.K401N	DO8336	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6918
p.L397V	DO228290	BRCA	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6765
p.E398D	DO51732	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.6758
p.P398S	TCGA-KL-8338	KICH	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.6752
p.L403V	DO233848	GACA	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.2778
p.L403V	DO38507	STAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.2778
p.P403H	LS-411N	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.2778
p.E392D	TCGA-O1-A52J	LUAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.2222
p.S392G	KM12	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.2222
p.P405H	LS-411N	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.2222
p.Q391H	TCGA-A6-3809	COAD	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.Q391H	TCGA-B5-A3FA	UCEC	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.Q391H	DO8722	COAD	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.Q391H	DO52402	UCEC	ICGC	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.S406N	GP5d	large_intestine	COSMIC	LTPGFT	DEG_SCF_FBW7_1	0.1944
p.D407N	TCGA-C5-A8XK	CESC	TCGA	LTPGFT	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51816	AF4/FMR2 family member 2	DEG_SCF_FBW7_1	396:401	LTPGFT	FBXW7	0.9957	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons