DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: LIG_APCC_ABBA_1

Location: 123:128

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7949

ASA_SCORE: 112.5333

COIL: 0.9627

CONS_SCORE: 0.4209

DSS_SCORE: 0.8056

HELIX: 0.0265

FCONS_SCORE: 0.9076

RIG_SCORE: 0.5958

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P132T	TCGA-38-4632	LUAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.2222
p.Q127H	TCGA-86-A456	LUAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.647
p.D128Y	TCGA-86-A456	LUAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.7325
p.T130A	TCGA-AA-A00N	COAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.2778
p.K119N	TCGA-AG-3892	READ	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.3333
p.K119N	TCGA-AP-A0LM	UCEC	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.3333
p.K119N	TCGA-EY-A1G8	UCEC	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.3333
p.P116S	TCGA-GN-A266	SKCM	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.1389
p.P137S	TCGA-VQ-A8P2	STAD	TCGA	IPPHQD	LIG_APCC_ABBA_1	0.0833
p.S136Y	DO6308	CESC	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.1111
p.S136Y	DO43041	UCEC	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.1111
p.T126A	DO9876	COAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.7139
p.P128A	DO222462	ESCA	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.7503
p.P128T	DO23858	LUAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.7031
p.D124Y	DO24890	LUAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.7325
p.D124Y	DO232472	PBCA	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.7325
p.Q123H	DO24890	LUAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.7582
p.P120L	DO220906	MELA	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.25
p.A130T	DO33032	PACA	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.2778
p.K115N	DO36394	READ	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.1111
p.K115N	DO43306	UCEC	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.1111
p.K115N	DO43578	UCEC	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.1111
p.P133S	DO51761	STAD	ICGC	IPPHQD	LIG_APCC_ABBA_1	0.1944
p.P132H	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	IPPHQD	LIG_APCC_ABBA_1	0.2222
p.P132H	ACH-000853	Lung Cancer	CCLE	IPPHQD	LIG_APCC_ABBA_1	0.2222
p.P132H	NCI-H661	lung	COSMIC	IPPHQD	LIG_APCC_ABBA_1	0.2222
p.M136V	SIDM01608	Endometrial Carcinoma	GDSC	IPPHQD	LIG_APCC_ABBA_1	0.1111
p.M136V	ACH-000990	Endometrial/Uterine Cancer	CCLE	IPPHQD	LIG_APCC_ABBA_1	0.1111
p.G124S	MCC13	skin	COSMIC	IPPHQD	LIG_APCC_ABBA_1	0.6993
p.S137L	KP-4	pancreas	COSMIC	IPPHQD	LIG_APCC_ABBA_1	0.0833
p.P128H	NCI-H661	lung	COSMIC	IPPHQD	LIG_APCC_ABBA_1	0.7694
p.E130K	KM12	large_intestine	COSMIC	IPPHQD	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPPHQD

Degron related mutations and impact score

Drug responses associated with AFF2 mutations

All proteins holding degron of IPPHQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51816	AF4/FMR2 family member 2	LIG_APCC_ABBA_1	123:128	IPPHQD	APC,CDC20,FZR1	0.7949	More...