DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: LIG_APCC_ABBA_1

Location: 48:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8693

ASA_SCORE: 56.3

COIL: 0.8237

CONS_SCORE: 0.5141

DSS_SCORE: 0.3153

HELIX: 0.0693

FCONS_SCORE: 1.2666

RIG_SCORE: 0.763

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K56N	TCGA-55-A492	LUAD	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.3611
p.K56N	DO23708	LUAD	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.3611
p.V57I	TCGA-AP-A059	UCEC	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.2222
p.D42N	TCGA-AP-A1DV	UCEC	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42N	TCGA-D3-A51T	SKCM	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42N	TCGA-EA-A6QX	CESC	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42N	DO48997	CESC	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42N	DO47389	SKCM	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42N	DO43186	UCEC	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42N	SIDM01588	Endometrial Carcinoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42N	ACH-000993	Endometrial/Uterine Cancer	CCLE	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.S45Y	TCGA-AX-A05Z	UCEC	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.25
p.S45Y	DO40884	UCEC	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.25
p.E59K	TCGA-BH-A18U	BRCA	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.E59K	TCGA-FD-A3SS	BLCA	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.E40K	TCGA-C5-A1BI	CESC	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.1111
p.E40K	DO44305	CESC	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.1111
p.D42Y	TCGA-E9-A1N5	BRCA	TCGA	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42Y	DO6195	BRCA	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.G60C	DO225012	BRCA	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.1389
p.N58S	DO222907	BTCA	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.1944
p.D49N	DO228648	GACA	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.5821
p.D49N	DO230535	LUSC	ICGC	FDLFGE	LIG_APCC_ABBA_1	0.5821
p.D41E	SIDM00845	Burkitt's Lymphoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	0.1389
p.D41E	SIDM01519	Head and Neck Carcinoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	0.1389
p.D41E	ACH-000786	Lymphoma	CCLE	FDLFGE	LIG_APCC_ABBA_1	0.1389
p.D41E	ACH-000992	Head and Neck Cancer	CCLE	FDLFGE	LIG_APCC_ABBA_1	0.1389
p.D41E	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	FDLFGE	LIG_APCC_ABBA_1	0.1389
p.D41E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	FDLFGE	LIG_APCC_ABBA_1	0.1389
p.D42H	SIDM00120	Prostate Carcinoma	GDSC	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42H	ACH-000979	Prostate Cancer	CCLE	FDLFGE	LIG_APCC_ABBA_1	0.1667
p.D42H	DU-145	prostate	COSMIC	FDLFGE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FDLFGE

Degron related mutations and impact score

Drug responses associated with AFF2 mutations

All proteins holding degron of FDLFGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51816	AF4/FMR2 family member 2	LIG_APCC_ABBA_1	48:53	FDLFGE	APC,CDC20,FZR1	0.8693	More...