DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: DEG_SCF_FBW7_1

Location: 369:374

E3 ligase: FBXW7

DEGRON score: 0.973

ASA_SCORE: 88.5167

COIL: 0.9377

CONS_SCORE: 0.3338

DSS_SCORE: 0.5718

HELIX: 0.0447

FCONS_SCORE: 0.8848

RIG_SCORE: 0.6767

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H366N	TCGA-05-4398	LUAD	TCGA	PTPLTS	DEG_SCF_FBW7_1	0.25
p.H366N	DO25847	LUAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.25
p.S374F	TCGA-09-2053	OV	TCGA	PTPLTS	DEG_SCF_FBW7_1	0.7982
p.S374F	DO31060	OV	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.7982
p.P371L	TCGA-DD-AAE0	LIHC	TCGA	PTPLTS	DEG_SCF_FBW7_1	0.7582
p.P371L	DO52253	LIHC	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.7582
p.S381Y	TCGA-FY-A3BL	THCA	TCGA	PTPLTS	DEG_SCF_FBW7_1	0.1389
p.S381Y	DO40190	THCA	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.1389
p.M364L	TCGA-G4-6295	COAD	TCGA	PTPLTS	DEG_SCF_FBW7_1	0.1944
p.M364L	DO9362	COAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.1944
p.R362Q	TCGA-JY-A93C	ESCA	TCGA	PTPLTS	DEG_SCF_FBW7_1	0.1389
p.R362W	TCGA-YU-A90P	TGCT	TCGA	PTPLTS	DEG_SCF_FBW7_1	0.1389
p.P369R	DO225215	BRCA	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.7512
p.P369R	DO227836	BRCA	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.7512
p.D374N	DO49904	CESC	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.6932
p.D374V	DO228648	GACA	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.7785
p.P365S	DO220346	KICH	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.2222
p.E359D	DO218948	LUAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.0556
p.P365L	DO23563	LUAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.2222
p.G366E	DO222843	MELA	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.25
p.S360L	DO32887	PACA	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.0833
p.M383I	DO47867	STAD	ICGC	PTPLTS	DEG_SCF_FBW7_1	0.0833
p.S374Y	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.S374Y	SIDM01199	Hepatocellular Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.S374Y	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.S374Y	SIDM00240	Cervical Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.S374Y	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.S374Y	OMC-1	cervix	COSMIC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.S374Y	KYSE-180	oesophagus	COSMIC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.S374Y	SNU-423	liver	COSMIC	PTPLTS	DEG_SCF_FBW7_1	0.712
p.R362L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PTPLTS	DEG_SCF_FBW7_1	0.1389
p.R362L	NCI-H650	lung	COSMIC	PTPLTS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SCF_FBW7_1	419:424	PTPLTS	FBXW7	0.578	More...
P51816	AF4/FMR2 family member 2	DEG_SCF_FBW7_1	369:374	PTPLTS	FBXW7	0.973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPLTS

Degron related mutations and impact score

Drug responses associated with AFF2 mutations

All proteins holding degron of PTPLTS